PCOL 824 Exam 2 Questions with Correct Answers

PCOL 824 Exam 2 Questions with Correct Answers What is the equation for Vd? - Answer-Vd = initial dose of drug in body / concentration of drug in plasma High Vd - Answer-Drug is mostly found in tissues - not affected by changes to protein binding - favored being present in the cells Low Vd - Answer-Drug is mostly in blood - very protein bound (albumin) - sensitive to changes in protein binding Order of Lowest to Highest Vd - Answer-Drug that highly binds to proteins and cannot enter the cell Water soluble drug but not really bound to proteins too much Drugs that bind and go into cells mostly ADME - Answer-Absorption, Distribution, Metabolism, Elimination Absorption - Answer-Transfer of drug from the site of administration to the circulating fluids of the body Distribution - Answer-REVERSIBLE - transfer of drug from the circulating fluids of the body to various tissues/organs EXCRETION - Answer-Elimination - IRREVERSIBLE - removal of drug from the body Physiological Barriers of drug ABSORPTION - Answer-Intestine - intestinal lumen, mucus layer, water layer Nervous System - BBB - many layers for capillaries for protection from getting into the brain Common routes of administration - Answer-SQ, IV, IM, PO (oral most common) Routes of Drug Administration - Answer-ENTERAL - into the gut - oral extravascular outside of the vascular system