Summary Virology assignment and short notes

VIROLOGY
=
:


→ Basis on which viruses are classified .


Order virales
-
corona ssRNA .




What is Ktv ? classificationon shape Viridae
→ →
Family
.
-




→ Terminal
Redundancy ? subfamily -
virinae
Viral needed ? Genus Virus
enzymes types why
→ -


, ,



"""" """" " " """ """""
→
"""
→ Icosahedral structure Pandorarims
lym
-




→
Enveloped viruses mimirirus
-0.74m
→
complex viruses Pandoravirus Salinas -2,5000 genes
material ?
How such less
genetic dulcis 4500genes
"
→ -




→ structure of rims ( components .
TMV → + VERNA -7 :
I group .




→ Virion , Virioid 1 subunit =) 3
proteins
definition Taka structural
Casper and Klug
→ virus
unit
of virus
.




→ Two
phases Triangulation .NO
→ viruses useful for ? all animal helical viruses are

?
→
Phage typing enveloped .




→ Functions of viral
proteins
? Hiv enveloped ,
helical -




→ difference b/w eukaryotes q prokaryotes ponvirws gemini .
, ,
complexions
Herpes simplex >
vaccines Cancer
treatment
those uniqueto Oculocutaneous albinism
enzymes catalyse
viral
'




:




[
viruses ↳ ° ↳ cured by gene
from RNA vector
mRNA
synthesis
.




DNAC viral) synthesis from
lack of melanin
RNA

vaccine virus ↳ HIV , retrovirus require reverse
transcriptase
↳ DNA dependent RNA
polymerase
HW


Endonuclease at
palindrome sequence .




Exonuclease at ends 32
page

, Viruses are classifiedon the basis of International committee of of viruses
ICTV taxonomy
→


diameter of virion RNA
polymerase acephagesretrovirus
-




of capsid
-



shape reverse
transcript ,
HIV

-



noofcapsomeres Baculorirus ,
myxoma pesticides .




-
no of
genes gene map
,
Herpes simplex virus vaccinations ,
Anti-cancer

material cured
type genetic
of OCA Oculouetanousalbanism bygenerator
-




/
Lysogenic lytogenic Acanthomoetapolyphagamimirines APMR
-




lipids proteins & Carbohydrates
enveloped not
,
-
or
>
envelope he " " '
immunological response symmetrical
-




capsid
-


-
icosahedral
> core
-
clinical features .




RNAIDNA of
-
location of DNA
replication ""
Protein
>
comprises
heoidity
variation
gggg.QR.p.gg
'
> controls
-
nature of host protein envelope germination
,
.




zFBf.EE?RNAandN
E-
protein intial cell membrane absorption .




Viral ←
→
Enzymes protein
enveloped helical vines
nucleic %gyg§→§ envelope
e.
Protein
↳ influenzae
necessary
for the
synthesis of
-




acid ICOSAHEDRAL STRICTURE :




Function of virus edges
protein ZOD 12 vertices 30
-



→
, ,




of
-



protection genetic material ↳
pentame.rs
i. 12 .




-
attachment to host >
equilateral triangles call same )
fusion with hosted/ membrane 3 axis of
symmetry 3 told fold Zfold
5
-


-
.
.


, , ,



theyre also usedas )
triangulation number number d- structural units (proteins
immune of host ↳ atleast 3in one subunit
enzymes
-
-

.




-




primers -




transcription factors structural units = 7×60

Viruses a re useful
for subunits in a
single face = total no of subunits
/ 20

HELICAL STRUCTURE
phage typing d- bacteria
:
-
=



of → Tobacco mosiac virus
source
.




enzymes
-




→ onemonomor surrounds DNA/ANA one side otitis heavier
pesticides generators
,
- _




i. ittormsa helix
aniti bacterial /cancer agents → Rabies
Influenzae .HN
, Herpes
.




.

EN ¥20s
-
:
☐

→ Howdorirushavesmall
genome
?
→
protein projects out spike protein orpeplomeres
host cell
use
proteins COMPLEX VIRUS :
-




/
core

membrane
-
code
efficiently overleapinggenes
-



Poxvinus brick
shape Nucleic
acid

multifunctionalproteins Outer

[ f- The DNA of
-
"


envelope
SHAPES OF VIRUS eucai.si#n-a-iSOMlVItUS ˢ%¥¥gens
anon




# \ µ lateral body
"

TAIL




spherical
PINS



filamentous ¥¥µ
# contains repeated sequences at its terminus
:: *
""
- ¥
-




spheroid
"




brick ↳ Terminal Redundancy
' '




- -




tadpole bullet
-



.
-
-

, V1
EPL/CATION :




ATTACHMENT
adheranceofvirus
→
particles to theplasma membrane
this isseeninthe attachment
very specific step
→ viruses are .




→
they bindtoaspecificreeeptorproteinonthecell surface
↳ these.pro/-einsarenotmadefo- attachment theyre present in ,


thecellandtherirusj.us/-aHachestoit .




→ cell
receptors or
receptors
co -

↳ so
they have
their own functions
E)
generalymadeupofglycoproteins ↳ chemokines →
receptor
↳ cell-cell contactand
rims select
receptors that are unique adhesion
→
aswell
and will affect
.




+ g those only cells .




receptor for rhinovirus KAMI


multiple receptors and be used
→ viruses
may
bind to ,
receptors can
by multiple
viruses .




→ virus first binds to receptor, ifitis.no/-suHicientitbindstoadiH-erentpotein ,




called
cosreceptor .




ENTRY INTO CELL Translocation Membrane Fusion .




Translocation →
only enveloped proteins
-




Membrane fusion host
home
fusion proteins to fuse with →
-



www.na.io →
receptor

Endocytosis cell
after receptors bind
-




.




virus translocated




;÷÷→÷÷¥→÷:É¥•
across membrane




Endocytosis
" "
"*

÷:&
.




-
Clathrin ② particle 's released
^




pH dependent
Cardin
into
€> cytoplasm
rhabdoirrus
→
influenzae
.




-


and
:*:& ,
.




Iatheincanolin independent →
pH independent herpesvirus.HN
-



.




¥É÷↳i;j;:É÷i÷:→ →
plant cells enters
throughout
material is released from the
Uncrating genetic before :
capsid .




attachment Guncoating simultaneously
- sometimes occurs even
entry eg
:

bacteriophage :
.




receptor triggers uncrating
others inside the cell PH
} triggers
-




presence of proteases
- .



-




at plasma membrane at nuclear membrane nuclear membrane
•
• with endosomes •
g)
I
=÷¥? ¥¥÷→☒→ /
±
I
→ ¥→ •
Eto ex
HERPES
:




SIMPLEX
?⃝