Clinical Pharmacology exam with
complete solutions
T or F:
Bioavailability is the percentage or fraction of the administered dose which
reaches systemic circulation - ANSWER- True
Name an example of a drug with zero order elimination - ANSWER- alcohol
You can assume a drug is completely cleared from the body after 1 half life -
ANSWER- false
the autonomic nervous system is divided into what two divisions - ANSWER-
sympathetic and parasympathetic
T or F:
A drug with anticholinergic side effects would cause constipation - ANSWER-
True
T or F
Barbiturates are widely used in medical practice now for anxiety and sleep -
ANSWER- False - have been replaced by benzodiazepine
Alprazolam is classified as what kind of drug? - ANSWER- Benzodiazepine
T or F
All antidepressants increase the concentration of norepinephrine or serotonin by
inhibiting the reuptake of those neurotransmitters - ANSWER- True
T or F
Haloperidol is an atypical antipsychotic (2nd generation) - ANSWER- False - 1st
generation
, Clozapine (Clozaril) has what potentially fatal side effect? - ANSWER-
agranulocytosis
T or F
Hypertension is defined as blood pressure higher than 140/90 - ANSWER- True
Mean arterial pressure = - ANSWER- cardiac output x peripheral resistance
Which diuretic is the drug of choice in primary hypertension? - ANSWER-
Thiazide diuretics
What is the most common side effect of ACEIs? - ANSWER- cough
Name one beta blocker - ANSWER- acebutolol
Treatment of heart failure is targeted towards - ANSWER- 1. decreasing cardiac
workload
2. controlling excess fluid
3. enhancing myocardial contractility
Name one symptom of CHF - ANSWER- shortness of breath
Which drug improves myocardial contractility and was originally isolated from
the digitalis purpurea plant? - ANSWER- cardiac glycosides (Lanoxin)
Vitamin K is the antidote to which oral anticoagulant? - ANSWER- warfarin
(Coumadin)
Which class of drugs is the first choice for hypercholesteremia? - ANSWER-
statins
Recognize the names of drugs in statin class - ANSWER- end in "-statin"
What is the main side effect of the statin drugs - ANSWER- myalgia (muscle pain)
How do statins work to lower cholesterol? - ANSWER- inhibit HMG CoA reductase
enzyme
Thrombolytic drugs are used to ______ or break up clots - ANSWER- lyse
major side effect of all anticoagulants is ____ - ANSWER- hemorrhage
complete solutions
T or F:
Bioavailability is the percentage or fraction of the administered dose which
reaches systemic circulation - ANSWER- True
Name an example of a drug with zero order elimination - ANSWER- alcohol
You can assume a drug is completely cleared from the body after 1 half life -
ANSWER- false
the autonomic nervous system is divided into what two divisions - ANSWER-
sympathetic and parasympathetic
T or F:
A drug with anticholinergic side effects would cause constipation - ANSWER-
True
T or F
Barbiturates are widely used in medical practice now for anxiety and sleep -
ANSWER- False - have been replaced by benzodiazepine
Alprazolam is classified as what kind of drug? - ANSWER- Benzodiazepine
T or F
All antidepressants increase the concentration of norepinephrine or serotonin by
inhibiting the reuptake of those neurotransmitters - ANSWER- True
T or F
Haloperidol is an atypical antipsychotic (2nd generation) - ANSWER- False - 1st
generation
, Clozapine (Clozaril) has what potentially fatal side effect? - ANSWER-
agranulocytosis
T or F
Hypertension is defined as blood pressure higher than 140/90 - ANSWER- True
Mean arterial pressure = - ANSWER- cardiac output x peripheral resistance
Which diuretic is the drug of choice in primary hypertension? - ANSWER-
Thiazide diuretics
What is the most common side effect of ACEIs? - ANSWER- cough
Name one beta blocker - ANSWER- acebutolol
Treatment of heart failure is targeted towards - ANSWER- 1. decreasing cardiac
workload
2. controlling excess fluid
3. enhancing myocardial contractility
Name one symptom of CHF - ANSWER- shortness of breath
Which drug improves myocardial contractility and was originally isolated from
the digitalis purpurea plant? - ANSWER- cardiac glycosides (Lanoxin)
Vitamin K is the antidote to which oral anticoagulant? - ANSWER- warfarin
(Coumadin)
Which class of drugs is the first choice for hypercholesteremia? - ANSWER-
statins
Recognize the names of drugs in statin class - ANSWER- end in "-statin"
What is the main side effect of the statin drugs - ANSWER- myalgia (muscle pain)
How do statins work to lower cholesterol? - ANSWER- inhibit HMG CoA reductase
enzyme
Thrombolytic drugs are used to ______ or break up clots - ANSWER- lyse
major side effect of all anticoagulants is ____ - ANSWER- hemorrhage
