A cute Lymphoid Leukemia Acute Myeloid Leukemia
of in BM
A cute Neoplastic proliferation of Lymphoid precursor cells Lymphoblast in BM Acute Neoplastic proliferation Myeloid precursor cells Ryeloblast
·
Maturation arrest - >
Lymphoblast 20 % in bone marrow .
·
Maturation arrest ->
Myeloblast 20 % in bone marrow .
decrease In Myeloid Lymphoid cells decrease
In Lymphoid Myeloid cells Leukemia >
·
Leukemia >
· -
-
Risk Factors : -Age = Children [2-10yas I Risk Factors :
-Age =
40-50 y Children y wh Down
Same MIC after Radiation
B =
Bloom Syndrome Benzene exposure
,
R Clinical Features : Same
Radiation
-
=
A =
Anemia [Fanconi's Aplastic] Ataxia
telengectasia
· ,
D = Down Syndrome Drugs [Chemo I FAB classification : -
[8 types I
,
V Virus [human EBVI Mo No differentiation Chlado ma Sweet Syndrome Leukemia cutis
=
T-lymphocyte virus ,
T = translocations [ + (12 : 21) + (8 : 14) t(s : 22) I M1 -
Minimal
, ,
Mz -
Maturation [t(8 :
21) Chloroma I
,
Clinical Features : -
My -
Promyelocytic [ + (15 ,
17)
,
DIC ,
Aver rods I
1) Anemia Paleness My [ + (16 16)
Gingival hyperplasia] Gingival hyperplasia
++t
Fatigue Dizziness -
Myelocytic ,
,
, ,
& Pancytopenia -
Recurrent infections Tachycardia Ms
-
Monocytic [Gingival hyperplasia Organ infiltration (H-S megaly) I
,
3) ↓ Platelet Petective Hypotension [Therapy related I
-
Gum
bleeding MG -
Erythroid
,
4) Painless lymphadenopath M7 -
Megakaryocytic [ / CD41 (Platelets) I
# Hepato splenomegaly
-
Abd pain
& Mediastenal Mass CNS involvement
In T cell
type of ALL WHO classification : -
1) AML with translocation [t(8 Good
:
21) + (13 ,
17) + (16 , 16) ] Prognosis
FAB classification -
> Not used 2) AML with therapy related
Who classification : 3) AML with Myelodysplastic Features Fitz mutation =
Bad
prognosis
-
Pre BALL Pre T ALL 4) AML NOS : Not Otherwis specified
1 Most common [80 %1. I * Less common [20 % I RAR
2) In Children Good
prognosis )
2 Adults Poor Prognosis t (15 17) ↑ 1
>
Fuse ↓ VitA > Musin
Promyelocyte DIC
·
,
, PMLRAR -
>
activity
-
>
-
S ,
3) PAX-5 EBF
gene
mutation 3) Notch I mutation
PML
,
· Mediastinal mass
· CNS involvement
of in BM
A cute Neoplastic proliferation of Lymphoid precursor cells Lymphoblast in BM Acute Neoplastic proliferation Myeloid precursor cells Ryeloblast
·
Maturation arrest - >
Lymphoblast 20 % in bone marrow .
·
Maturation arrest ->
Myeloblast 20 % in bone marrow .
decrease In Myeloid Lymphoid cells decrease
In Lymphoid Myeloid cells Leukemia >
·
Leukemia >
· -
-
Risk Factors : -Age = Children [2-10yas I Risk Factors :
-Age =
40-50 y Children y wh Down
Same MIC after Radiation
B =
Bloom Syndrome Benzene exposure
,
R Clinical Features : Same
Radiation
-
=
A =
Anemia [Fanconi's Aplastic] Ataxia
telengectasia
· ,
D = Down Syndrome Drugs [Chemo I FAB classification : -
[8 types I
,
V Virus [human EBVI Mo No differentiation Chlado ma Sweet Syndrome Leukemia cutis
=
T-lymphocyte virus ,
T = translocations [ + (12 : 21) + (8 : 14) t(s : 22) I M1 -
Minimal
, ,
Mz -
Maturation [t(8 :
21) Chloroma I
,
Clinical Features : -
My -
Promyelocytic [ + (15 ,
17)
,
DIC ,
Aver rods I
1) Anemia Paleness My [ + (16 16)
Gingival hyperplasia] Gingival hyperplasia
++t
Fatigue Dizziness -
Myelocytic ,
,
, ,
& Pancytopenia -
Recurrent infections Tachycardia Ms
-
Monocytic [Gingival hyperplasia Organ infiltration (H-S megaly) I
,
3) ↓ Platelet Petective Hypotension [Therapy related I
-
Gum
bleeding MG -
Erythroid
,
4) Painless lymphadenopath M7 -
Megakaryocytic [ / CD41 (Platelets) I
# Hepato splenomegaly
-
Abd pain
& Mediastenal Mass CNS involvement
In T cell
type of ALL WHO classification : -
1) AML with translocation [t(8 Good
:
21) + (13 ,
17) + (16 , 16) ] Prognosis
FAB classification -
> Not used 2) AML with therapy related
Who classification : 3) AML with Myelodysplastic Features Fitz mutation =
Bad
prognosis
-
Pre BALL Pre T ALL 4) AML NOS : Not Otherwis specified
1 Most common [80 %1. I * Less common [20 % I RAR
2) In Children Good
prognosis )
2 Adults Poor Prognosis t (15 17) ↑ 1
>
Fuse ↓ VitA > Musin
Promyelocyte DIC
·
,
, PMLRAR -
>
activity
-
>
-
S ,
3) PAX-5 EBF
gene
mutation 3) Notch I mutation
PML
,
· Mediastinal mass
· CNS involvement
