Please write clearly in block capitals.
Centre number Candidate number
Surname
Forename(s)
Candidate signature
I declare this is my own work.
GCSE
COMBINED SCIENCE: TRILOGY
Foundation Tier
F
Biology Paper 2F
Friday 7 June 2024 Afternoon Time allowed: 1 hour 15 minutes
Materials
For Examiner’s Use
For this paper you must have:
• a ruler Question Mark
• a scientific calculator.
1
Instructions 2
• Use black ink or black ball-point pen. 3
• Pencil should only be used for drawing. 4
• Fill in the boxes at the top of this page.
5
• Answer all questions in the spaces provided.
• If you need extra space for your answer(s), use the lined pages at the end of 6
this book. Write the question number against your answer(s).
TOTAL
• Do all rough work in this book. Cross through any work you do not want to be
marked.
• In all calculations, show clearly how you work out your answer.
Information
• The maximum mark for this paper is 70.
• The marks for questions are shown in brackets.
• You are expected to use a calculator where appropriate.
• You are reminded of the need for good English and clear presentation in your answers.
*Jun248464B2F01*
IB/M/Jun24/G4005/E8 8464/B/2F
, 2
Do not write
outside the
0 1 Cystic fibrosis is a genetic disorder. box
0 1 . 1 Cystic fibrosis affects the movement of substances into and out of cells.
Which part of a cell controls the movement of substances into and out of the cell?
[1 mark]
Tick () one box.
Cell membrane
Cytoplasm
Mitochondria
Cystic fibrosis is caused by a recessive allele, b.
0 1 . 2 What name is given to the allele B?
[1 mark]
Tick () one box.
DNA
Dominant
Gene
0 1 . 3 Which term describes the genotype Bb?
[1 mark]
Tick () one box.
Chromosome
Heterozygous
Phenotype
*02*
IB/M/Jun24/8464/B/2F
, 3
Do not write
outside the
0 1 . 4 Two people plan to have a child. box
Both people have the genotype Bb.
Complete Figure 1 to show the possible genotypes of the child.
[3 marks]
Figure 1
0 1 . 5 What is the chance that a child of these parents will have cystic fibrosis?
Use Figure 1.
[1 mark]
Tick () one box.
0% 25% 50% 75%
Question 1 continues on the next page
Turn over ►
*03*
IB/M/Jun24/8464/B/2F
, 4
Do not write
outside the
0 1 . 6 An embryo can be tested to find out its genotype. box
What is the name of the testing process?
[1 mark]
Tick () one box.
Genetic engineering
Screening
Selective breeding
0 1 . 7 Inherited disorders can be caused by changes in DNA.
What is the name of a change in DNA?
[1 mark]
Tick () one box.
Genome
Helix
Mutation
0 1 . 8 Inheritance is one cause of variation in a population.
Environmental factors also cause variation in a population.
Suggest one environmental cause of variation in a human population.
Do not refer to inheritance or to changes in DNA in your answer.
[1 mark]
10
*04*
IB/M/Jun24/8464/B/2F
Centre number Candidate number
Surname
Forename(s)
Candidate signature
I declare this is my own work.
GCSE
COMBINED SCIENCE: TRILOGY
Foundation Tier
F
Biology Paper 2F
Friday 7 June 2024 Afternoon Time allowed: 1 hour 15 minutes
Materials
For Examiner’s Use
For this paper you must have:
• a ruler Question Mark
• a scientific calculator.
1
Instructions 2
• Use black ink or black ball-point pen. 3
• Pencil should only be used for drawing. 4
• Fill in the boxes at the top of this page.
5
• Answer all questions in the spaces provided.
• If you need extra space for your answer(s), use the lined pages at the end of 6
this book. Write the question number against your answer(s).
TOTAL
• Do all rough work in this book. Cross through any work you do not want to be
marked.
• In all calculations, show clearly how you work out your answer.
Information
• The maximum mark for this paper is 70.
• The marks for questions are shown in brackets.
• You are expected to use a calculator where appropriate.
• You are reminded of the need for good English and clear presentation in your answers.
*Jun248464B2F01*
IB/M/Jun24/G4005/E8 8464/B/2F
, 2
Do not write
outside the
0 1 Cystic fibrosis is a genetic disorder. box
0 1 . 1 Cystic fibrosis affects the movement of substances into and out of cells.
Which part of a cell controls the movement of substances into and out of the cell?
[1 mark]
Tick () one box.
Cell membrane
Cytoplasm
Mitochondria
Cystic fibrosis is caused by a recessive allele, b.
0 1 . 2 What name is given to the allele B?
[1 mark]
Tick () one box.
DNA
Dominant
Gene
0 1 . 3 Which term describes the genotype Bb?
[1 mark]
Tick () one box.
Chromosome
Heterozygous
Phenotype
*02*
IB/M/Jun24/8464/B/2F
, 3
Do not write
outside the
0 1 . 4 Two people plan to have a child. box
Both people have the genotype Bb.
Complete Figure 1 to show the possible genotypes of the child.
[3 marks]
Figure 1
0 1 . 5 What is the chance that a child of these parents will have cystic fibrosis?
Use Figure 1.
[1 mark]
Tick () one box.
0% 25% 50% 75%
Question 1 continues on the next page
Turn over ►
*03*
IB/M/Jun24/8464/B/2F
, 4
Do not write
outside the
0 1 . 6 An embryo can be tested to find out its genotype. box
What is the name of the testing process?
[1 mark]
Tick () one box.
Genetic engineering
Screening
Selective breeding
0 1 . 7 Inherited disorders can be caused by changes in DNA.
What is the name of a change in DNA?
[1 mark]
Tick () one box.
Genome
Helix
Mutation
0 1 . 8 Inheritance is one cause of variation in a population.
Environmental factors also cause variation in a population.
Suggest one environmental cause of variation in a human population.
Do not refer to inheritance or to changes in DNA in your answer.
[1 mark]
10
*04*
IB/M/Jun24/8464/B/2F
