PA BOARDS HEMATOLOGY CHEAT SHEET, HEMATOLOGY AND
ONCOLOGY PANCE/PANRE, HEMATOLOGY PEARLS (1),
HEMATOLOGY, HEMATOLOGY/ONCOLOGY WORD
ASSOCIATIONS PANCE/PANRE EXAM QUESTIONS WITH
VERIFIED ANSWERS 2024/2025
Megaloblastic. Peripheral neuropathy MMA
B12 Deficiency
Megaloblastic. No neuro symptoms
Folate Deficiency
Blood loss. Microcytic. Low ferritin.
Iron Deficiency
Increased LDH, reticulocyte, Indirect bilirubin. Decreased
haptoglobin.
Hemolysis
Pancytopenia Low retic count. Bone biopsy.
Aplastic Anemia
X-linked enzyme deficiency. Infection. Fava beans. Bite cells. Heinz body
G6PD deficiency
Most common bleeding disorder. Elevated aPTT. Von willebrand factor activity.
RIPA. Desmopressin
Von Willebrand
,X-linked recessive disorder. Hemarthrosis. Normal Platelets.
prolonged aPTT.
Hemophilia
Thrombophilia. DVT. PE. No screening.
Factor V Leiden
Anticardiolipin antibody. Recurrent pregnancy loss. Prolonged aPTT. Russel
Viper Venom test. DVT
Antiphospholipid Syndrome
4 > days. Thrombosis. ELISA. Venous limb gangrene
Heparin Induced Thrombocytopenia
Shiga Toxin producing E COLI 0157:H7. Quinine. Microangiopathic hemolytic
anemia and thrombocytopenia.
Immune Thrombocytopenia
65. Myeloid. Auer rod Phi bodies. M3 all-trans-retinoic acid. > 20% blasts
AML
Children. Lymphoid. > 20% blasts. TdT
ALL
Neutrophils. Basophilia. Leukocytosis. 9:22 translocation.
Philadelphia chromosome Tyrosine Kinase Inhibitor.
CML (Philadelphia cream cheese)
Non functioning B cells. Lymphadenopathy. Lymphocytosis Flow cytometry.
Rituximab.
CLL
,Painless cervical lymphadenopathy. B symptoms. Reed Sternberg cells.
Mediastinal mass. Excisional node biopsy
Hodgkin Lymphoma
Plasma cells. IgG, IgA. Bence Jones Protein Rouleaux Formation. > 10% clonal
plasma cells
Multiple Myeloma
Vaso occlusion. Hemolytic anemia. Cold, Hypoxia, alcohol,
infection. Howell Jolly bodies. Penicillin < 5 years of age. Hydroxyurea.
Sickle cell
Auer rods on peripheral smear indicate...
acute myeloblastic leukemia (AML)
60 year old male with severe anemia, decreased neutrophil count, and small,
abnormal B lymphocytes in the bone marrow (>30%) with levels at 90,000 per
cubic millimeter. Has painless cervical lymphadenopathy and
hepatosplenomegaly. Likely diagnosis?
Chronic lymphocytic leukemia (CLL)
Bone marrow aspiration and biopsy reveals the presence of the Philadelphia (Ph)
chromosome in dividing marrow cells. Likely diagnosis?
Chromic myeloblastic leukemia (CML)
Follicular, cleaved cell, lymphocytic, histolytic
Hodgkins Lymphoma
Reed Sternberg cell
Hodgkin's lymphoma
, Plasma cells, monoclonal protein
Multiple myeloma
What disease is characterized by abnormal monoclonal protein, anemia, and lytic
bone lesions?
Multiple myeloma
30 year old white male with 3 month history of painless enlargement of bilateral
cervical lymph nodes, fever, and night sweats. Likely diagnosis?
Hodgkin's disease
What hematologic measurement is abnormal in chronic heavy alcohol use?
Mean corpuscular volume
Most frequent cause of B12 deficiency in patients with classic pernicious anemia
Lack of intrinsic factor
In thalassemia anemia, what causes the anemia?
Shortened lifespan of RBCs
Teenage African American female presents with severe bone and joint pain. CBC
shows severe anemia and elevate leukocyte and platelet counts. Most likely
diagnosis?
Sickle cell disease
What 2 tests are used to confirm the diagnosis of homozygous sickle cell
disease?
Peripheral smear and hemoglobin electrophoresis
The most helpful test to distinguish megaloblastic from nonmegaloblastic
macrocytic anemia
ONCOLOGY PANCE/PANRE, HEMATOLOGY PEARLS (1),
HEMATOLOGY, HEMATOLOGY/ONCOLOGY WORD
ASSOCIATIONS PANCE/PANRE EXAM QUESTIONS WITH
VERIFIED ANSWERS 2024/2025
Megaloblastic. Peripheral neuropathy MMA
B12 Deficiency
Megaloblastic. No neuro symptoms
Folate Deficiency
Blood loss. Microcytic. Low ferritin.
Iron Deficiency
Increased LDH, reticulocyte, Indirect bilirubin. Decreased
haptoglobin.
Hemolysis
Pancytopenia Low retic count. Bone biopsy.
Aplastic Anemia
X-linked enzyme deficiency. Infection. Fava beans. Bite cells. Heinz body
G6PD deficiency
Most common bleeding disorder. Elevated aPTT. Von willebrand factor activity.
RIPA. Desmopressin
Von Willebrand
,X-linked recessive disorder. Hemarthrosis. Normal Platelets.
prolonged aPTT.
Hemophilia
Thrombophilia. DVT. PE. No screening.
Factor V Leiden
Anticardiolipin antibody. Recurrent pregnancy loss. Prolonged aPTT. Russel
Viper Venom test. DVT
Antiphospholipid Syndrome
4 > days. Thrombosis. ELISA. Venous limb gangrene
Heparin Induced Thrombocytopenia
Shiga Toxin producing E COLI 0157:H7. Quinine. Microangiopathic hemolytic
anemia and thrombocytopenia.
Immune Thrombocytopenia
65. Myeloid. Auer rod Phi bodies. M3 all-trans-retinoic acid. > 20% blasts
AML
Children. Lymphoid. > 20% blasts. TdT
ALL
Neutrophils. Basophilia. Leukocytosis. 9:22 translocation.
Philadelphia chromosome Tyrosine Kinase Inhibitor.
CML (Philadelphia cream cheese)
Non functioning B cells. Lymphadenopathy. Lymphocytosis Flow cytometry.
Rituximab.
CLL
,Painless cervical lymphadenopathy. B symptoms. Reed Sternberg cells.
Mediastinal mass. Excisional node biopsy
Hodgkin Lymphoma
Plasma cells. IgG, IgA. Bence Jones Protein Rouleaux Formation. > 10% clonal
plasma cells
Multiple Myeloma
Vaso occlusion. Hemolytic anemia. Cold, Hypoxia, alcohol,
infection. Howell Jolly bodies. Penicillin < 5 years of age. Hydroxyurea.
Sickle cell
Auer rods on peripheral smear indicate...
acute myeloblastic leukemia (AML)
60 year old male with severe anemia, decreased neutrophil count, and small,
abnormal B lymphocytes in the bone marrow (>30%) with levels at 90,000 per
cubic millimeter. Has painless cervical lymphadenopathy and
hepatosplenomegaly. Likely diagnosis?
Chronic lymphocytic leukemia (CLL)
Bone marrow aspiration and biopsy reveals the presence of the Philadelphia (Ph)
chromosome in dividing marrow cells. Likely diagnosis?
Chromic myeloblastic leukemia (CML)
Follicular, cleaved cell, lymphocytic, histolytic
Hodgkins Lymphoma
Reed Sternberg cell
Hodgkin's lymphoma
, Plasma cells, monoclonal protein
Multiple myeloma
What disease is characterized by abnormal monoclonal protein, anemia, and lytic
bone lesions?
Multiple myeloma
30 year old white male with 3 month history of painless enlargement of bilateral
cervical lymph nodes, fever, and night sweats. Likely diagnosis?
Hodgkin's disease
What hematologic measurement is abnormal in chronic heavy alcohol use?
Mean corpuscular volume
Most frequent cause of B12 deficiency in patients with classic pernicious anemia
Lack of intrinsic factor
In thalassemia anemia, what causes the anemia?
Shortened lifespan of RBCs
Teenage African American female presents with severe bone and joint pain. CBC
shows severe anemia and elevate leukocyte and platelet counts. Most likely
diagnosis?
Sickle cell disease
What 2 tests are used to confirm the diagnosis of homozygous sickle cell
disease?
Peripheral smear and hemoglobin electrophoresis
The most helpful test to distinguish megaloblastic from nonmegaloblastic
macrocytic anemia
