CORRECT ANSWERS LATEST UPLOAD 2024/2025 FOR A
GUARANTEED PASS
Key drugs that can cause hypothyroidism - ANSWER--"I TALC"
Interferons
Tyrosine Kinase Inhibitors
Amiodarone
Lithium
Carbamazepine
Conditions: Hashimoto's disease
Levothyroxine IV:PO - ANSWER--0.75:1 (IV:PO)
Full replacement dose levothyroxine - ANSWER--1.6 mcg/kg/day (IBW)
If known CAD: start with 12.5-25 mcg daily
Levothyroxine tablet colors - ANSWER--Orangutans Will Vomit On You Right
Before They Become Large Proud Giants
25 Orange
50 White (no dye)
75 Violet
88 Olive
100 Yellow
112 Rose
125 Brown
, NAPLEX EXAM 2025 WITH 1000+ QUESTIONS AND
CORRECT ANSWERS LATEST UPLOAD 2024/2025 FOR A
GUARANTEED PASS
137 Turquoise
150 Blue
175 Lilac
200 Pink
300 Green
Drug induced causes of hyperthyroidism - ANSWER--Iodine
Amiodarone
Interferons
Radiographic contrast media
treatment for thyroid storm - ANSWER--Antithyroid (PTU preferred- give 1 hour
before iodide)
Inorganic iodide therapy (SSKI or Lugol's)
Beta Blocker (Propranolol)
Systemic steroid (dexamethasone)
Aggressive cooling (APAP, cooling blankets, supportive treatments)
Hyperthyroid in pregnancy - ANSWER--Hyperthyroidism during pregnancy
should be treated with propylthiouracil (PTU) during the first trimester then
methimazole during the second and third trimesters. Although methimazole is a
teratogen, the teratogenic effects are less during the second and third trimesters,
and PTU can cause liver failure, which is why it is substituted out.
, NAPLEX EXAM 2025 WITH 1000+ QUESTIONS AND
CORRECT ANSWERS LATEST UPLOAD 2024/2025 FOR A
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Cushing's syndrome - ANSWER--Adrenal gland produces too much cortisol or
exogenous steroids are taken in doses higher than normal amounts of endogenous
cortisol
Addison's disease - ANSWER--a condition that occurs when the adrenal glands do
not produce enough cortisol; Addisonian crisis (volume depletion and hypotension,
which can be fatal)
Steroids: least to most potent - ANSWER--(Cute Hot Pharmacists and Physicians
Marry Together & Deliver Babies)
o Cortisone (25 mg): short acting
o Hydrocortisone (20 mg): short acting
o Prednisone (5 mg): intermediate acting
o Prednisolone (5 mg): intermediate acting
o Methylprednisolone (4 mg): intermediate acting
o Triamcinolone (4 mg): intermediate acting
o Dexamethasone (0.75 mg): long acting, highest potency
o Betamethasone (0.6 mg): long acting, highest potency
Immunosuppression from steroids - ANSWER--A patient is immunosuppressed
when using >/= 2mg/kg/day or >/= 20mg/day of prednisone or prednisone
equivalent for >2 weeks
Immunosuppressed patients cannot receive live vaccines and have a high risk of
infection
, NAPLEX EXAM 2025 WITH 1000+ QUESTIONS AND
CORRECT ANSWERS LATEST UPLOAD 2024/2025 FOR A
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steroid will need to be slowly tapered off: reduce 10-20% every few days (tapers
can last 7-14 days, longer or shorter)
Traditional DMARDs (disease modifying anti-rheumatic drugs) - ANSWER--
MTX (Trexall): first line in RA
Hydroxychloroquine (Plaquenil)
Sulfasalazine
Leflunomide (Arava)
Traditional DMARDs (disease modifying anti-rheumatic drugs): MTX -
ANSWER--MTX (Trexall): first line in RA
- irreversibly binds and inhibit dihydrofolate reductase, inhibiting folate
- 7.5 to 20 mg once weekly
- hepatotoxicity (avoid alcohol), myelosuppression, mucosistis/stomatitis,
teratogenic
- monitor: CBC, LFTs, chest X-ray, hep B/C
- folate replacement
- renal elimination is decreased by aspirin/NSAIDs
Traditional DMARDs (disease modifying anti-rheumatic drugs):
hydroxychloroquine - ANSWER--Hydroxychloroquine (Plaquenil)
- Irreversible retinopathy
- take with food or milk
- alternative to MTX in liver disease