2025 NBME SUBJECT TESTS
QUESTIONS WITH VERIFIED
ANSWERS ALREADY GRADED A+
26 month old boy with SOB & cough who had cutaneous abscesses caused by S.
aureus. febrile, x-ray shows cavitary infiltrate of left lingula. Culture grows
filamentous gram + rods. Answer choices are
A. Bacillus anthracis
B. Candida
C. Nocardia
D. Pneumocystis
E. Strep bovis - CORRECT ANSWER>>>>C. Nocardia
increased conc estradiol and decrd conc of progesterone. On which of the
following days in this patient`s menstrual cycle were these hormones most likely
measured?
A) Day 1
B) Day 6
c) Day 12
D) Day 18
E) Day 26 - CORRECT ANSWER>>>>c) Day 12
18/21-Decr Estrogen, Incr Prog
lumbar puncture is performed and the results of polymerase chain reaction testing
of CSF show herpes simplec virus. It is most appropiate to administer a drug that
inhibits which of the following viral enzymes?
Dna polymerase
Neuraminidase
Protease
Reverse transcriptase
RNase A - CORRECT ANSWER>>>>DNA polymerase
-[Acyclovir- Guanosine analog. Monophosphorylated by HSV/VZV thymidine
kinase and not phosphorylated in uninfected cells Preferentially inhibit viral DNA
polymerase by chain termination.]
,-Neuraminidase- Oseltamivir, zanamivir- Influenza
begins to laugh while eating dinner with his friends. A small particle of food
irritates his larynx and provokes him to cough. Which of the following best
describes the position of his vocal cords throughout this sequence?
While swallowing //Immediately after Laryngeal irritation// While coughing
A. Closed Closed Open
B. Closed Open Closed
C. Closed Open Open
D. Open Closed Closed
E. Open Closed Open
F. Open Open Closed - CORRECT ANSWER>>>>- swallowing--> closed.
-immediately after laryngeal irritation --->closed
-while coughing -->open
25 y/o man is brought to EMD because of abdominal pain, nausea, vomiting + Pain
originates in the left flank and radiates to his groin; Diagnosis
A. colon neoplasm
B. diverticulitis
C. epididymitis
D. renal infarction
E. torsion of testis
F. ureteral calculus - CORRECT ANSWER>>>>F.urethral calculus
A F comes to the physician bc of progressive difficulty walking during the past 3
months. Neurologic exam: weakness and decreased muscle bulk of the lower
extremities. Patellar and Achilles tendon reflexes are diminished. Sensations of
joint position, pain, and temperature in the lower extremities normal. Which of the
following is the most likely cause of the findings in this patient?
A) Acute peripheral neuropathy
B) Degeneration of motoneurons of the lumbar cord
C) Demyelination of the corticospinal pathways
D) Loss of afferent la axons innervating muscle spindles
E) Myotonic muscular dystrophy - CORRECT ANSWER>>>>B) Degeneration of
motoneurons of the lumbar cord
,woman is brought to ED 30 minutes after the sudden onset of severe headache. on
arrival, her blood pressure is 163/90 mm Hg. the right pupil is 6 mm and
nonreactive to light. adduction of the right eye is impaired. Nuchal rigidity is
noted. A CT scan of the head shows Blood in the subarachnoid space. Cerebral
aniography is most likely to show an Aneurysm in which of the following arteries?
A) Anterior Cerebral
B) Internal Carotid
C) Middle Cerebral
D) posterior communiating
E) Vertebral - CORRECT ANSWER>>>>D) posterior communiating
[Blown pupil]
Two days after undergoing a right hip replacement operation, a 67-years-old
woman has shortness of breath and pain on the side of her back with deep
breathing. She appears anxious. Her pulse is 100/min, and respirations are 24/min.
A pleureal friction rub is heard in the right lung base. Examination of the right calf
shows erythema and induration. Immediate treatment with oxygen, 4L/min via
nasal cannula, is initiadet. Arterial blood gas analysis shows:
ph: 7.54
pCO2: 29 mmHg
pO2: 61 mmHg
CT angiography of the chest shows a large embolism occluding blood flow to the
right lower lobe. Which of the following best describes the current ventilation-
perfusion relationship in the right lobe of this patient?
A) Dead space
B) Diffusion abnormality
C) Hypoventilation
D) Low FiO2
E) Shunt - CORRECT ANSWER>>>>A) Dead space
16-year-old girl 20 minutes after generalized tonic-clinic seizure at home. Two
more seizures after arrival. Unable to urinate, confused. P 120/min rr 24min, BP
170/109. Enlarged uterus. Ultrasonography shows normal fetus consistent in size
with 30-week gestation. Diagnosis? - CORRECT ANSWER>>>>Eclampsia
, 55-year-old man comes to the physician because of a 3-day history of fever, chills,
nausea, vomiting, and diarrhea. He says he has been unable to eat or drink anything
without vomiting and has had little urine production during the past 12 hours. His
temperature is 37.8°C (100°F). His pulse is 92/min, and blood pressure is 110/70
mm Hg while supine; pulse is 110/min, and blood pressure is 80/60 mm Hg while
standing. Physical examination shows dry mucous membranes and a soft abdomen
with mild, diffuse tenderness. Laboratory studies :
Leukocyte count 7200/mm3
Serum:
Na+ 146 mEq/L
Urea nitrogen 50 mg/dL
Creatinine 2.2 mg/dL
Uric acid 10.2 mg/dL
Urine:
Specific gravity 1.030
RBC 0/hpf
Protein negative
Na+ 10 mEq/L
Creatinine 19 mg/dL
Which of the following is the most likely cause of the laboratory findings in this
patient?
A.Acute tubular necrosis
B.Bladder outlet obstruction
C.Interstitial nephritis
D.Membranous gl - CORRECT ANSWER>>>>E.Volume depletion
9-mo old brought to ED bcof severe respiratory distress for 1 hr. respirations
80/min. 3rd percentile for lenght and weight. Physical exam: shows cyanosis.
Despite appropriate measures, the pt dies. Autopsy findings show a ventricular
septal defect and persistent truncus arteriosus. Which of the following populations
of cells was most likely absent during early fetal cardiac development in this
patient?
A) Ectodermal neural crest
B) Extraembryonic mesoderm
C) Mantle layer neuroblasts
D) Mesothelial cells
QUESTIONS WITH VERIFIED
ANSWERS ALREADY GRADED A+
26 month old boy with SOB & cough who had cutaneous abscesses caused by S.
aureus. febrile, x-ray shows cavitary infiltrate of left lingula. Culture grows
filamentous gram + rods. Answer choices are
A. Bacillus anthracis
B. Candida
C. Nocardia
D. Pneumocystis
E. Strep bovis - CORRECT ANSWER>>>>C. Nocardia
increased conc estradiol and decrd conc of progesterone. On which of the
following days in this patient`s menstrual cycle were these hormones most likely
measured?
A) Day 1
B) Day 6
c) Day 12
D) Day 18
E) Day 26 - CORRECT ANSWER>>>>c) Day 12
18/21-Decr Estrogen, Incr Prog
lumbar puncture is performed and the results of polymerase chain reaction testing
of CSF show herpes simplec virus. It is most appropiate to administer a drug that
inhibits which of the following viral enzymes?
Dna polymerase
Neuraminidase
Protease
Reverse transcriptase
RNase A - CORRECT ANSWER>>>>DNA polymerase
-[Acyclovir- Guanosine analog. Monophosphorylated by HSV/VZV thymidine
kinase and not phosphorylated in uninfected cells Preferentially inhibit viral DNA
polymerase by chain termination.]
,-Neuraminidase- Oseltamivir, zanamivir- Influenza
begins to laugh while eating dinner with his friends. A small particle of food
irritates his larynx and provokes him to cough. Which of the following best
describes the position of his vocal cords throughout this sequence?
While swallowing //Immediately after Laryngeal irritation// While coughing
A. Closed Closed Open
B. Closed Open Closed
C. Closed Open Open
D. Open Closed Closed
E. Open Closed Open
F. Open Open Closed - CORRECT ANSWER>>>>- swallowing--> closed.
-immediately after laryngeal irritation --->closed
-while coughing -->open
25 y/o man is brought to EMD because of abdominal pain, nausea, vomiting + Pain
originates in the left flank and radiates to his groin; Diagnosis
A. colon neoplasm
B. diverticulitis
C. epididymitis
D. renal infarction
E. torsion of testis
F. ureteral calculus - CORRECT ANSWER>>>>F.urethral calculus
A F comes to the physician bc of progressive difficulty walking during the past 3
months. Neurologic exam: weakness and decreased muscle bulk of the lower
extremities. Patellar and Achilles tendon reflexes are diminished. Sensations of
joint position, pain, and temperature in the lower extremities normal. Which of the
following is the most likely cause of the findings in this patient?
A) Acute peripheral neuropathy
B) Degeneration of motoneurons of the lumbar cord
C) Demyelination of the corticospinal pathways
D) Loss of afferent la axons innervating muscle spindles
E) Myotonic muscular dystrophy - CORRECT ANSWER>>>>B) Degeneration of
motoneurons of the lumbar cord
,woman is brought to ED 30 minutes after the sudden onset of severe headache. on
arrival, her blood pressure is 163/90 mm Hg. the right pupil is 6 mm and
nonreactive to light. adduction of the right eye is impaired. Nuchal rigidity is
noted. A CT scan of the head shows Blood in the subarachnoid space. Cerebral
aniography is most likely to show an Aneurysm in which of the following arteries?
A) Anterior Cerebral
B) Internal Carotid
C) Middle Cerebral
D) posterior communiating
E) Vertebral - CORRECT ANSWER>>>>D) posterior communiating
[Blown pupil]
Two days after undergoing a right hip replacement operation, a 67-years-old
woman has shortness of breath and pain on the side of her back with deep
breathing. She appears anxious. Her pulse is 100/min, and respirations are 24/min.
A pleureal friction rub is heard in the right lung base. Examination of the right calf
shows erythema and induration. Immediate treatment with oxygen, 4L/min via
nasal cannula, is initiadet. Arterial blood gas analysis shows:
ph: 7.54
pCO2: 29 mmHg
pO2: 61 mmHg
CT angiography of the chest shows a large embolism occluding blood flow to the
right lower lobe. Which of the following best describes the current ventilation-
perfusion relationship in the right lobe of this patient?
A) Dead space
B) Diffusion abnormality
C) Hypoventilation
D) Low FiO2
E) Shunt - CORRECT ANSWER>>>>A) Dead space
16-year-old girl 20 minutes after generalized tonic-clinic seizure at home. Two
more seizures after arrival. Unable to urinate, confused. P 120/min rr 24min, BP
170/109. Enlarged uterus. Ultrasonography shows normal fetus consistent in size
with 30-week gestation. Diagnosis? - CORRECT ANSWER>>>>Eclampsia
, 55-year-old man comes to the physician because of a 3-day history of fever, chills,
nausea, vomiting, and diarrhea. He says he has been unable to eat or drink anything
without vomiting and has had little urine production during the past 12 hours. His
temperature is 37.8°C (100°F). His pulse is 92/min, and blood pressure is 110/70
mm Hg while supine; pulse is 110/min, and blood pressure is 80/60 mm Hg while
standing. Physical examination shows dry mucous membranes and a soft abdomen
with mild, diffuse tenderness. Laboratory studies :
Leukocyte count 7200/mm3
Serum:
Na+ 146 mEq/L
Urea nitrogen 50 mg/dL
Creatinine 2.2 mg/dL
Uric acid 10.2 mg/dL
Urine:
Specific gravity 1.030
RBC 0/hpf
Protein negative
Na+ 10 mEq/L
Creatinine 19 mg/dL
Which of the following is the most likely cause of the laboratory findings in this
patient?
A.Acute tubular necrosis
B.Bladder outlet obstruction
C.Interstitial nephritis
D.Membranous gl - CORRECT ANSWER>>>>E.Volume depletion
9-mo old brought to ED bcof severe respiratory distress for 1 hr. respirations
80/min. 3rd percentile for lenght and weight. Physical exam: shows cyanosis.
Despite appropriate measures, the pt dies. Autopsy findings show a ventricular
septal defect and persistent truncus arteriosus. Which of the following populations
of cells was most likely absent during early fetal cardiac development in this
patient?
A) Ectodermal neural crest
B) Extraembryonic mesoderm
C) Mantle layer neuroblasts
D) Mesothelial cells
