11jExamj3j|jUPDATE|COMPREHENSIVEjQUESTI nctionjinjinfants?
ONSjANDjVERIFIED A. Renaljbloodjflowjreachesjadultjvaluesjbyj1jm
SOLUTIONS/CORRECTjANSWERS|GETj100%j onthjofjage
ACCURATE!! B. Dosingjrecommendationsjforjrenally
eliminatedjdrugsjtypicallyjdojnotjdependjonjp
ost-nataljage
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rejreachedjbyj2jweeksjafterjbirth
D. Tubularjsecretionjandjreabsorptionjprocessesja
rejimmaturejatjbirth
4
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rnjtwojweeksjago.jHerjbirthweightjisj1.5
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jmenstrualjage?
educesjbonejturnoverjmarkers A. 2jweeksjpost-nataljage;j29jweeksjpost-
jmenstrualjage
Increasesjcorticaljandjtrabecularjbonejmassjandjst B. 2jweeksjpost-nataljage;j33jweeksjpost-
rength jmenstrualjage
C. 31jweeksjpost-nataljage;j2jweeksjpost-
Reboundjfracturesjinjthejvertebraejcanjoccurjaf jmenstrualjage
terjdiscontinuation D. 31jweeksjpost-nataljage;j33jweeksjpost-
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pregnancy B
3
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natesjrelativejtojadults?
nctionjinjinfants?
A. Maturationjinjplasmajproteinsjthatjbindjtojd
A. Renaljbloodjflowjreachesjadultjvaluesjbyj1jm
rugs
onthjofjage
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B. Dosingjrecommendationsjforjrenally
C. Maturationjinjdrugjtransportersjthatjimpactjc
eliminatedjdrugsjtypicallyjdojnotjdependjonjp
entraljnervousjsystemjpenetration
ost-nataljage
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B rejreachedjbyj2jweeksjafterjbirth
D. Tubularjsecretionjandjreabsorptionjprocessesja
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rejimmaturejatjbirth
hatjage?
A. 1jyearjofjage D
B. 1jmonthjofjage
Whichjofjthejfollowingjequationsjisjusedjcomm
C. 6-8jmonthsjofjage
onlyjtojestimatejcreatininejclearancejinjthejped
D. 2jyearsjofjagej
iatricjpopulation?
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B. Cockcroft-Gaultjformula
Whichjofjthejfollowingjfactorsjcanjalterjdrugjdi
C. ModificationjofjDietjinjRenaljDiseasej(MDRD)jst
stributionjinjinfants?
udyjformula
A. Lessjskinjhydration
B. Changesjinjtotaljbodyjwaterjandjtotaljbodyjfa A
tjwithjage
Penicillinsjundergojglomerularjfiltrationjand
C. Drug-
tubularjsecretion.jWhichjofjthejfollowingjmayjb
drugjinteractionsjthatjleadjtojdrugjmetaboli
ejtruejaboutjthejhalf-
smjinhibition
lifejofjeliminationjforjpenicillinsjinjinfants?
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A. Nojchangejinjhalf-lifejofjelimination
ntestines
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B lifejofjeliminationjduejtojreducedjglomerul
arjfiltrationjandjtubularjsecretion
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C. Shorterjhalf-lifejofjeliminationjduejto
dependsjonjwhichjofjthejfollowingjfactors?
increasedjglomerularjfiltrationjandjtubularjs
A. Bindingjaffinityjforjthejprotein
ecretion
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metabolizingjenzymes
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agej
postmenstrual
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agejisjcalculatedjbyjsubtractingjthejn
umberjofjweeksjbornjbeforej40jweeksjfromjthej
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phabeticaljorder)
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st-nataljage
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rm?
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rm?
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oderate-to-latejpreterm?
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sjisjkindajinjajlimbo)
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eterm?
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extremelyjpreterm?jBornjbefore
wee
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ryjlowjbirthjweightjisjbelow
kg
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2.5
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writtenjsolutionjtojthisjproblem!
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0-1jmonthj(post-nataljage)
Whatjisjthejagejrangejforjinfants?j
28jdays-1jyear
Whatjisjthejagejrangejforjtoddlers?
Whatjisjthejagejrangejforjearlyjchildhood?jW
hatjisjthejagejrangejforjmiddlejchildhood?jW
hatjisjthejagejrangejforjearlyjadolescence?jW
hatjisjthejagejrangejforjlatejadolescence?
1-2jyears
2-5jyears
6-11jyears
12-18jyears
19-21jyears
Whichjofjthejfollowingjisjnotjajreasonjthatjp
ediatricjdrugjdevelopmentjisjdifficult?
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state/lowjratesjofjparentaljinformedjconsent
(b) youjcannotjethicallyjtestjmedicationsjinj
"healthy"jchildjvolunteers
(c) wejalreadyjhavejplentyjofjgoodjdrugsjforj
children