NSG 6665 TEST 2: HEMATOLOGY| QUESTIONS WITH VERIFIED ANSWERS 100% SOLVED|
LATEST UPDATE GUARANTEED PASS
Thrombocytopenia labs A coagulation factor deficiency is possible when the platelet count is
normal and either the PT or aPTT is prolonged ( could be both PT and aPTT is prolonged).
ITP (idiopathic thrombocytopenic purpura) •Benign self-limited disorder
•Most common ages 1-4 yrs
•Usually follows viral infection
•usually resolves within 6 mo
•Antiplatelet antibodies bind to platelets which are then destroyed by the spleen
•Severe bleeding rare
•Spontaneous remission
most common cause of the thrombocytopenic purpuras in childhood ITP
hemophilia types •Hemophilia A (Factor VIII deficiency)- classic hemophilia
•Hemophilia B (Factor IX deficiency) - Christmas Disease
•Hemophilia C (Factor Xl deficiency)- von Willebrands Disease
hemophilia caused by •A and B are X-linked recessive
•Males almost exclusively affected (have disease)
•Female with trait may be symptomatic
•Von Williebrand is autosomal recessive
•Males and females equally affected
,where does bleeding occur in hemophilia •Bleeding in A and B typically occurs in muscles,
soft tissues, joints and is delayed
•Bleeding in C is usually mucous membranes, or skin
WBC by age Newborn: 9,000-30,000/ mm3
3 months: 6,000-18,000
6 mon-6yrs: 6,000-18,000
7 - 12 years: 4,500-13,500
Adult: 5,000- 10,000 / mm3
the neutrophilic response leukocyte increase as a defensive mechanism in response to
bacterial infections
Granulocytes neutrophils, eosinophils, basophils
Agranulocytes lymphocytes and monocytes
more granulocytes or agranulocytes 40-70% granulocytes
major WBC in bacterial infection fight neutrophil s
Eosinophils function -help moderate allergic reactions
-defend against parasites
Basophils function viral infections
, Lymphocytosis abnormal increase in lymphocytes
Lymphocytosis cause viral infections
neutropenia deficiency of neutrophils
2 weeks-1 yo <1000
>1 yo <1500
neutropenia cause •reduced cellular production
•increased peripheral destruction
•severe bacterial infections
neutropenia manifestations •bacterial infections
•malaise, fever, chills
•weakness
•agranulocytosis
leukemia Malignant neoplasm of hematopoietic stem cells characterized by diffuse
replacement of bone marrow by neoplastic cells
blast cells leukemia baby cells
neutropenia deficiency of neutrophils-extreme risk for bacterial infection - usually caused by
chemo
most common childhood cancer leukemia - 26% of ped cancers <15 yo
LATEST UPDATE GUARANTEED PASS
Thrombocytopenia labs A coagulation factor deficiency is possible when the platelet count is
normal and either the PT or aPTT is prolonged ( could be both PT and aPTT is prolonged).
ITP (idiopathic thrombocytopenic purpura) •Benign self-limited disorder
•Most common ages 1-4 yrs
•Usually follows viral infection
•usually resolves within 6 mo
•Antiplatelet antibodies bind to platelets which are then destroyed by the spleen
•Severe bleeding rare
•Spontaneous remission
most common cause of the thrombocytopenic purpuras in childhood ITP
hemophilia types •Hemophilia A (Factor VIII deficiency)- classic hemophilia
•Hemophilia B (Factor IX deficiency) - Christmas Disease
•Hemophilia C (Factor Xl deficiency)- von Willebrands Disease
hemophilia caused by •A and B are X-linked recessive
•Males almost exclusively affected (have disease)
•Female with trait may be symptomatic
•Von Williebrand is autosomal recessive
•Males and females equally affected
,where does bleeding occur in hemophilia •Bleeding in A and B typically occurs in muscles,
soft tissues, joints and is delayed
•Bleeding in C is usually mucous membranes, or skin
WBC by age Newborn: 9,000-30,000/ mm3
3 months: 6,000-18,000
6 mon-6yrs: 6,000-18,000
7 - 12 years: 4,500-13,500
Adult: 5,000- 10,000 / mm3
the neutrophilic response leukocyte increase as a defensive mechanism in response to
bacterial infections
Granulocytes neutrophils, eosinophils, basophils
Agranulocytes lymphocytes and monocytes
more granulocytes or agranulocytes 40-70% granulocytes
major WBC in bacterial infection fight neutrophil s
Eosinophils function -help moderate allergic reactions
-defend against parasites
Basophils function viral infections
, Lymphocytosis abnormal increase in lymphocytes
Lymphocytosis cause viral infections
neutropenia deficiency of neutrophils
2 weeks-1 yo <1000
>1 yo <1500
neutropenia cause •reduced cellular production
•increased peripheral destruction
•severe bacterial infections
neutropenia manifestations •bacterial infections
•malaise, fever, chills
•weakness
•agranulocytosis
leukemia Malignant neoplasm of hematopoietic stem cells characterized by diffuse
replacement of bone marrow by neoplastic cells
blast cells leukemia baby cells
neutropenia deficiency of neutrophils-extreme risk for bacterial infection - usually caused by
chemo
most common childhood cancer leukemia - 26% of ped cancers <15 yo
