1
(VERIFIED NR 565)
NR 565 ADVANCED PHARMACOLOGY
MIDTERM – CHAMBERLAIN SET OF
QUESTIONS WITH CORRECT ANSWERS
What is the CYP450 (cytochrome P450)
liver enzyme system where medications are metabolized, can either be inducers or
inhibitors and create drug-drug interactions
Do you need informed consent for genetic testing?
yes
What is the purpose of the Genetic Information Non-Discriminatory Act?
Protects patients from discrimination by employers and insurance providers based
on genetic information
Difference between practice authority and prescriptive authority?
Practice authority refers to the nurse practitioner's ability to practice without
physician oversight, whereas prescriptive authority refers to the nurse practitioner's
authority to prescribe medications independently and without limitations.
Who regulates prescriptive authority?
the jurisdiction of a health professional board. This may be the State Board of
Nursing, the State Board of Medicine, or the State Board of Pharmacy, as
determined by each state.
What is scope of practice determined by?
is determined by state practice and licensure laws.
What is full practice authority?
Nurse practitioners have the autonomy to evaluate patients, diagnose, order and
interpret tests, initiate and manage treatments and prescribe medications, including
controlled substances without physician oversight
What is restricted practice authority?
, 2
(VERIFIED NR 565)
Nurse practitioners are limited in at least one element of practice by requiring
supervision, delegation, or team management by an outside health discipline for
the nurse practitioner to provide patient care.- typically doctor on site
What are black box warnings?
Is the strongest safety warning a drug can carry and still remain on the market.
Usually presented on the label with a heavy black border.
Why are black box warnings issued?
Issued by the FDA due to having serious or life-threatening risks
What is neonate and infant drug dosing based on?
weight or body surface area (BSA)
CYP450 inducers
Speed up metabolism of drugs (drug is cleared faster), drug has lesser effect
(decrease blood levels of drug), elevate CYP450 enzymes
CYP450 inducers pneumonic
"Bullshit Crap GPS INDUCES rage"
CYP450 inducer drug names
Barbituates, St John wort, Carbamazepine, rifampin, alcohol, phenytoin,
griseofulvin, phenobarbital, sulfonylureas
CYP450 inhibitors
inhibit metabolism, increase blood levels of medications
CYP450 pneumonic
"VISA credit card debt INHIBITS spending on designers like CK to look GQ"
CYP450 inhibitors drug names
Valproate, isoniazid, sulfonamides, amiodarone, chloramphenicol, ketoconazole,
grapefruit juice, quinidine
, 3
(VERIFIED NR 565)
Physiological changes during pregnancy that impact pharmacodynamics and
pharmacokinetic properties of drugs?
increase glomerular filtration rate leads to increase durg excretion
increase hepatic metabolism
decrease tone and motility of bowel
increase drug absorption
Examples of medications that can be teratogenic
Antiepileptic drugs, antimicrobials such as tetracyclines and fluoroquinolones,
vitamin A in large doses, some anticoagulants, and hormonal medications such as
diethylstilbestrol (DES).
How is absorption of intramuscular medications different in neonates?
slow and erratic due to low blood flow in muscles first few days of life
Why is absorption of medication in the stomach increased in infancy?
delayed gastric emptying
Some medications that should be avoided in the pediatric patient?
glucocorticoids, discoloration of developing teeth with tetracyclines, and
kernicterus with sulfonamides, levofloxacin (antibiotics)
aspirin (Severe intoxication from acute overdose)
what should be included in medication administration patient education?
dosage size and timing
route and technique of administration
duration of treatment
drug storage
nature and time course of desired responses
nature and time course of adverse responses
finish taking antibiotic
, 4
(VERIFIED NR 565)
What are some things that put the elderly patient at higher risk for adverse drug
reactions?
reduced renal function
polypharmacy (the use of five or more medications daily)
greater severity of illness
presence of comorbidities
use of drugs that have a low therapeutic index (e.g., digoxin)
increased individual variation secondary to altered pharmacokinetics
inadequate supervision of long-term therapy
poor patient adherence
How can healthcare providers decrease likelihood of an elderly patient
experiencing an adverse drug reaction?
obtaining a thorough drug history that includes over-the-counter medications
considering pharmacokinetic and pharmacodynamics changes due to age
monitoring the patient's clinical response and plasma drug levels
using the simplest regimen possible
monitoring for drug-drug interactions and iatrogenic illness
periodically reviewing the need for continued drug therapy
encouraging the patient to dispose of old medications
taking steps to promote adherence and to avoid drugs on the Beers list
How can we promote medication adherence with elderly patients?
simplifying drug regimens
providing clear and concise verbal and written instructions
using an appropriate dosage form
clearly labeling and dispensing easy-to-open containers
developing daily reminders
(VERIFIED NR 565)
NR 565 ADVANCED PHARMACOLOGY
MIDTERM – CHAMBERLAIN SET OF
QUESTIONS WITH CORRECT ANSWERS
What is the CYP450 (cytochrome P450)
liver enzyme system where medications are metabolized, can either be inducers or
inhibitors and create drug-drug interactions
Do you need informed consent for genetic testing?
yes
What is the purpose of the Genetic Information Non-Discriminatory Act?
Protects patients from discrimination by employers and insurance providers based
on genetic information
Difference between practice authority and prescriptive authority?
Practice authority refers to the nurse practitioner's ability to practice without
physician oversight, whereas prescriptive authority refers to the nurse practitioner's
authority to prescribe medications independently and without limitations.
Who regulates prescriptive authority?
the jurisdiction of a health professional board. This may be the State Board of
Nursing, the State Board of Medicine, or the State Board of Pharmacy, as
determined by each state.
What is scope of practice determined by?
is determined by state practice and licensure laws.
What is full practice authority?
Nurse practitioners have the autonomy to evaluate patients, diagnose, order and
interpret tests, initiate and manage treatments and prescribe medications, including
controlled substances without physician oversight
What is restricted practice authority?
, 2
(VERIFIED NR 565)
Nurse practitioners are limited in at least one element of practice by requiring
supervision, delegation, or team management by an outside health discipline for
the nurse practitioner to provide patient care.- typically doctor on site
What are black box warnings?
Is the strongest safety warning a drug can carry and still remain on the market.
Usually presented on the label with a heavy black border.
Why are black box warnings issued?
Issued by the FDA due to having serious or life-threatening risks
What is neonate and infant drug dosing based on?
weight or body surface area (BSA)
CYP450 inducers
Speed up metabolism of drugs (drug is cleared faster), drug has lesser effect
(decrease blood levels of drug), elevate CYP450 enzymes
CYP450 inducers pneumonic
"Bullshit Crap GPS INDUCES rage"
CYP450 inducer drug names
Barbituates, St John wort, Carbamazepine, rifampin, alcohol, phenytoin,
griseofulvin, phenobarbital, sulfonylureas
CYP450 inhibitors
inhibit metabolism, increase blood levels of medications
CYP450 pneumonic
"VISA credit card debt INHIBITS spending on designers like CK to look GQ"
CYP450 inhibitors drug names
Valproate, isoniazid, sulfonamides, amiodarone, chloramphenicol, ketoconazole,
grapefruit juice, quinidine
, 3
(VERIFIED NR 565)
Physiological changes during pregnancy that impact pharmacodynamics and
pharmacokinetic properties of drugs?
increase glomerular filtration rate leads to increase durg excretion
increase hepatic metabolism
decrease tone and motility of bowel
increase drug absorption
Examples of medications that can be teratogenic
Antiepileptic drugs, antimicrobials such as tetracyclines and fluoroquinolones,
vitamin A in large doses, some anticoagulants, and hormonal medications such as
diethylstilbestrol (DES).
How is absorption of intramuscular medications different in neonates?
slow and erratic due to low blood flow in muscles first few days of life
Why is absorption of medication in the stomach increased in infancy?
delayed gastric emptying
Some medications that should be avoided in the pediatric patient?
glucocorticoids, discoloration of developing teeth with tetracyclines, and
kernicterus with sulfonamides, levofloxacin (antibiotics)
aspirin (Severe intoxication from acute overdose)
what should be included in medication administration patient education?
dosage size and timing
route and technique of administration
duration of treatment
drug storage
nature and time course of desired responses
nature and time course of adverse responses
finish taking antibiotic
, 4
(VERIFIED NR 565)
What are some things that put the elderly patient at higher risk for adverse drug
reactions?
reduced renal function
polypharmacy (the use of five or more medications daily)
greater severity of illness
presence of comorbidities
use of drugs that have a low therapeutic index (e.g., digoxin)
increased individual variation secondary to altered pharmacokinetics
inadequate supervision of long-term therapy
poor patient adherence
How can healthcare providers decrease likelihood of an elderly patient
experiencing an adverse drug reaction?
obtaining a thorough drug history that includes over-the-counter medications
considering pharmacokinetic and pharmacodynamics changes due to age
monitoring the patient's clinical response and plasma drug levels
using the simplest regimen possible
monitoring for drug-drug interactions and iatrogenic illness
periodically reviewing the need for continued drug therapy
encouraging the patient to dispose of old medications
taking steps to promote adherence and to avoid drugs on the Beers list
How can we promote medication adherence with elderly patients?
simplifying drug regimens
providing clear and concise verbal and written instructions
using an appropriate dosage form
clearly labeling and dispensing easy-to-open containers
developing daily reminders
