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2025/2026 AG-ACNP Exam Mastery – 75 Clinical Questions with Verified Answers | Cardiology, GI, Neuro, Pulmonary, Infectious Disease & More

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This in-depth AG-ACNP exam preparation guide delivers 75 high-quality, board-style clinical questions paired with clear, accurate answers and concise explanations, fully aligned with the 2025/2026 Adult-Gerontology Acute Care Nurse Practitioner (AG-ACNP) certification standards. Designed for advanced practice students and professionals, this resource simulates real exam conditions and challenges learners with a wide range of case-based scenarios that mirror the complexity of acute care. Topics span across multiple high-yield systems and disciplines: Cardiology: valvular pathologies (e.g. mitral regurgitation, S3 gallop), heart failure, post-MI care, lipid management, and shock recognition Gastrointestinal: Crohn's disease, diverticulitis, ulcerative colitis, and SBO diagnostics Neurology: stroke vs TIA, Babinski reflex, seizure management, trauma-related findings Pulmonary & Infectious Disease: pneumonia confirmation, TB diagnostics, post-intubation pneumonia, and pulmonary embolism Endocrine and Metabolic: DKA management, Cushing’s diagnostics, adrenal and thyroid dysfunctions Musculoskeletal & Hematology: rheumatoid arthritis markers, anemia types, and compartment syndrome Pharmacology & Immunization: MOAs of drugs like niacin, prednisone, epinephrine, antihypertensives, and vaccine recommendations Ethics, Billing & Practice: Medicare/Medicaid coverage, incident-to billing, patient safety, and crisis response This guide is ideal for both structured studying and rapid review. It also helps sharpen differential diagnosis, prioritize interventions, and make informed decisions under pressure—skills critical for success on the AG-ACNP board exam and in clinical practice. Who this document is for: MSN or DNP students specializing in Adult-Gerontology Acute Care Nurse Practitioner tracks Nurse practitioners preparing for the ANCC or AACN AG-ACNP certification exams Acute care residents and advanced practice clinicians reviewing core concepts across systems NP educators, clinical faculty, and preceptors seeking practice questions to supplement didactic or clinical teaching Keywords: AGACNP exam questions, adult gerontology board review, acute care NP study guide, cardiology murmur identification, SBO and IBD, mitral regurgitation, shock types, TB diagnosis, pneumonia confirmation, RA markers, DKA treatment, compartment syndrome, billing rules Medicare, ACLS drug use, pulmonary embolism test, stroke workup, anemia differentiation

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AG-ACNP DRT #3 2025/2026 Exam
Questions and Answers | A+ Score
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Patient c/o wrist and hand pain, swollen, redness and pain that is worse in the

morning and resolves as the day goes on. What findings would support your

suspected diagnosis of RA?

a. narrowing of joint space

b. osteophyes

c. elevated ESR


d. juxta-articular - 🧠 ANSWER ✔✔elevated ESR


Patient presents nausea, vomiting, dehydrated and anxious. Friends reported

finding empty bottle of ASA by patient's bed. What is the primary intervention? - 🧠

ANSWER ✔✔AC via OGT

,You are examining a patient with PMH of seizures. Patients sustains a seizure

lasting around 12 minutes during exam. What is the most appropriate intervention?

- 🧠 ANSWER ✔✔diazepam (Valium) 5-10 mg IV


urine Na 28, serum osmolality 250, urine osmolality 115. Suspected cause? - 🧠

ANSWER ✔✔SIADH


True or False: Barium enema is indicated in the conservative management of

diverticulitis. - 🧠 ANSWER ✔✔false


Patient has low diastolic rumble murmur in the left lateral position with no

radiation. What murmur do you suspect? - 🧠 ANSWER ✔✔mitral stenosis


Which of the following labs would you not expect to see in a patient that presents

with Cushing's:

a. hypokalemia

b. glucosuria

c. hypernatremia


d. hypoglycemia - 🧠 ANSWER ✔✔hypoglycemia


At what age do males start colonoscopy every 10 years? - 🧠 ANSWER ✔✔50

, Which of the following drugs cause lupus-like symptoms:

a. beta blocker

b. ASA

c. procanamide


d. sertaline - 🧠 ANSWER ✔✔procandmide


35 yo. F presents to ED with c/o b/l wrist pain. You suspect spousal abuse. You

notice a handgun in the patients purse. What would be your next action?

a. contact social services about spousal abuse

b. take the handgun away from the patient

c. call security to ensure safety


d. call the police and report a dangerous weapon - 🧠 ANSWER ✔✔security to

ensure safety

You patient is worried about insurance coverage and asks you for advice on

Medicaid. You instruct the patient that Medicaid pays:

a. patient pays 80% of bill

b. for individuals that cannot afford health care



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