Med Org - violet PACOP Exam 300 Questions
and Verified Correct Answers latest 2025–2026
1. The functional group attached to the acyl amino group is called a/an:
A) Phenoxyethyl
B) Isoxazoyl
C) Imidazole
D) Benzyl
E) Methoxypheny - answer>>>B) Isoxazoyl
2. Halogen substituents are best placed in what position?
A) 1,2-substitution
B) 1,3-substitution
C) 1,4-substitution
D) BothAandB
E) BothAandC - answer>>>A) 1,2-substitution
3. This antibiotic is primarily indicated for what type of infection?
A) Klebsiella
B) Enterobacter
C) Psudomonas
D) Staphylococci
E) Streptococi - answer>>>D) Staphylococci
4. Adding more than 1 chloride atoms in the structure confers what modification on the
pharmacokinetic profile of the drug?
A) Liberation
B) Absorption
C) Distribution
D) Metabolism
E) Excretion - answer>>>C) Distribution
5. What is the role of chloride atoms in the structure?
A) Increase the susceptibility to penicillinase
B) Increasing the plasma concentration
C) Acid resistance property
D) Increase in parenteral absorption
E) Increase in oral absorption - answer>>>B) Increasing the plasma concentration
6. Preservatives like parabens increase their preservative property by
,A) Reducing the parent compound
B) Decreasing molecular weight
C) Attaching a halogen to the parent compound
D) Substituting the parent compound with a
lipophilic group
E) Increasing the molecular weight - answer>>>E) Increasing the molecular weight
7. Sodium pump is an example of A.)enzyme-linked tyrosine kinase receptor B.) G-protein coupled
receptor
C.) Ion- channel
D.)Gene transcription-linked receptor
E.) None of the above - answer>>>C.) Ion- channel
8. This is an approach in drug discovery wherein there is already an existing drug that can be used
to identify a new lead compound?
A) Random Screening
B) Molecular Docking
C) Parent compound modification
D) Biotechnology techniques
E) Rational Drug Design - answer>>>A) Random Screening
9. Azeotropic distillation of benzene is done in what concentration of ethanol?
A) 95%
B) 70%
C) 50%
D) 99%
E) 10% - answer>>>D) 99%
10. Radical reactions may also proceed using this reagent
A) Bromine water
B) Hydrogen peroxide
C) Nitric acid
D) Sodium oxalate
E) Potassium bitartrate - answer>>>B) Hydrogen peroxide
For
numbers 11-14, refer to the series of the reaction
11. What is the reagent needed for the first reaction?
A) NaOH/ Oxidizing agent
B) CH3 Cl/AlCl3
C) HNO3/H2SO4
,D) NaOH/ Reducing agent
E) CH3Br/NaNH2 - answer>>>B) CH3 Cl/AlCl3
12. The product formed with the reaction is
A) Benzyl alcohol
B) Phenol
C) Benzoic acid
D) Xylene
E) Anisole - answer>>>C) Benzoic acid
13. The reagent needed for the reaction to proceed is
A) CH3Br/NaNH2
B) NaOH/Reducing agent
C) CH3COCl/AlCl3
D) HNO3/H2SO4
E) NaOH/ Oxidizing agent - answer>>>D) HNO3/H2SO4
14. The reagent needed for the reaction to proceed is
A) NaOH/Oxidizing agent
B) CH3Br/NaNH2/NO2
C) H2O/H2SO4
D) NaOH/Reducing agent
E) NBS - answer>>>D) NaOH/Reducing agent
15. When a carbonyl group reacts with a secondary amine, what will be the resulting product?
A) Imine
B) Amide
C) Tertiary amine
D) Enamine
E) Secondary amine - answer>>>D) Enamine
16. The addition of hydrogen molecule to an alkene is catalyzed by what metal?
A) Silver
B) Palladium
C) Berrylium
D) Gallium
E) Osmium - answer>>>B) Palladium
17. Methoxybenzene is also known as _____
A) Anisole B) Toluene C) Aniline D) Xylene E) Anethole - answer>>>A) Anisole
, 18. Which of the following compounds can be use to synthesize primary alcohol?
A) Propane
B) Formaldehyde C) 3-chloropentane D) Acetone
E) Ethanamine - answer>>>A) Propane
19. Which of the following cephalosporin is excreted in bile?
A) Cefixime
B) Cefotaxime C) Ceftriaxone D) Moxalactam E) Loracarbef - answer>>>C) Ceftriaxone
21. Preservatives use for molds
A) Ethylparaben
B) Methylparaben C) Butylparaben
D) Propylparaben E) Isopropylparaben - answer>>>B) Methylparaben
22. Which is true about drug absorption?
I. For weakly acidic drug, it must e in its
unionized form
II. For weakly acidic drug, it must be in its
ionized form
III. For weakly basic drug, it must be in its
unionized form
IV. For weakly basic drug, it must be in its
ionized form
A) I, II, III B) I and III
C) II and IV
D) III and IV
E) I and III - answer>>>E) I and III
23. This anti-convulsant compound is susceptible to what metabolic pathway?
A) Aromatic hydroxylation
B) Methylation
C) Sulfate conjugation
D) Oxidative deamination
E) GSH conjugation - answer>>>A) Aromatic hydroxylation
For numbers 24-26, refer to the general structure of penicillin
24. Which of the following will confer resistance against beta lactamases when synthesizing
analogs of penicillin?
A) Halogens
B) Ring deactivators
C) Electron withdrawing group
and Verified Correct Answers latest 2025–2026
1. The functional group attached to the acyl amino group is called a/an:
A) Phenoxyethyl
B) Isoxazoyl
C) Imidazole
D) Benzyl
E) Methoxypheny - answer>>>B) Isoxazoyl
2. Halogen substituents are best placed in what position?
A) 1,2-substitution
B) 1,3-substitution
C) 1,4-substitution
D) BothAandB
E) BothAandC - answer>>>A) 1,2-substitution
3. This antibiotic is primarily indicated for what type of infection?
A) Klebsiella
B) Enterobacter
C) Psudomonas
D) Staphylococci
E) Streptococi - answer>>>D) Staphylococci
4. Adding more than 1 chloride atoms in the structure confers what modification on the
pharmacokinetic profile of the drug?
A) Liberation
B) Absorption
C) Distribution
D) Metabolism
E) Excretion - answer>>>C) Distribution
5. What is the role of chloride atoms in the structure?
A) Increase the susceptibility to penicillinase
B) Increasing the plasma concentration
C) Acid resistance property
D) Increase in parenteral absorption
E) Increase in oral absorption - answer>>>B) Increasing the plasma concentration
6. Preservatives like parabens increase their preservative property by
,A) Reducing the parent compound
B) Decreasing molecular weight
C) Attaching a halogen to the parent compound
D) Substituting the parent compound with a
lipophilic group
E) Increasing the molecular weight - answer>>>E) Increasing the molecular weight
7. Sodium pump is an example of A.)enzyme-linked tyrosine kinase receptor B.) G-protein coupled
receptor
C.) Ion- channel
D.)Gene transcription-linked receptor
E.) None of the above - answer>>>C.) Ion- channel
8. This is an approach in drug discovery wherein there is already an existing drug that can be used
to identify a new lead compound?
A) Random Screening
B) Molecular Docking
C) Parent compound modification
D) Biotechnology techniques
E) Rational Drug Design - answer>>>A) Random Screening
9. Azeotropic distillation of benzene is done in what concentration of ethanol?
A) 95%
B) 70%
C) 50%
D) 99%
E) 10% - answer>>>D) 99%
10. Radical reactions may also proceed using this reagent
A) Bromine water
B) Hydrogen peroxide
C) Nitric acid
D) Sodium oxalate
E) Potassium bitartrate - answer>>>B) Hydrogen peroxide
For
numbers 11-14, refer to the series of the reaction
11. What is the reagent needed for the first reaction?
A) NaOH/ Oxidizing agent
B) CH3 Cl/AlCl3
C) HNO3/H2SO4
,D) NaOH/ Reducing agent
E) CH3Br/NaNH2 - answer>>>B) CH3 Cl/AlCl3
12. The product formed with the reaction is
A) Benzyl alcohol
B) Phenol
C) Benzoic acid
D) Xylene
E) Anisole - answer>>>C) Benzoic acid
13. The reagent needed for the reaction to proceed is
A) CH3Br/NaNH2
B) NaOH/Reducing agent
C) CH3COCl/AlCl3
D) HNO3/H2SO4
E) NaOH/ Oxidizing agent - answer>>>D) HNO3/H2SO4
14. The reagent needed for the reaction to proceed is
A) NaOH/Oxidizing agent
B) CH3Br/NaNH2/NO2
C) H2O/H2SO4
D) NaOH/Reducing agent
E) NBS - answer>>>D) NaOH/Reducing agent
15. When a carbonyl group reacts with a secondary amine, what will be the resulting product?
A) Imine
B) Amide
C) Tertiary amine
D) Enamine
E) Secondary amine - answer>>>D) Enamine
16. The addition of hydrogen molecule to an alkene is catalyzed by what metal?
A) Silver
B) Palladium
C) Berrylium
D) Gallium
E) Osmium - answer>>>B) Palladium
17. Methoxybenzene is also known as _____
A) Anisole B) Toluene C) Aniline D) Xylene E) Anethole - answer>>>A) Anisole
, 18. Which of the following compounds can be use to synthesize primary alcohol?
A) Propane
B) Formaldehyde C) 3-chloropentane D) Acetone
E) Ethanamine - answer>>>A) Propane
19. Which of the following cephalosporin is excreted in bile?
A) Cefixime
B) Cefotaxime C) Ceftriaxone D) Moxalactam E) Loracarbef - answer>>>C) Ceftriaxone
21. Preservatives use for molds
A) Ethylparaben
B) Methylparaben C) Butylparaben
D) Propylparaben E) Isopropylparaben - answer>>>B) Methylparaben
22. Which is true about drug absorption?
I. For weakly acidic drug, it must e in its
unionized form
II. For weakly acidic drug, it must be in its
ionized form
III. For weakly basic drug, it must be in its
unionized form
IV. For weakly basic drug, it must be in its
ionized form
A) I, II, III B) I and III
C) II and IV
D) III and IV
E) I and III - answer>>>E) I and III
23. This anti-convulsant compound is susceptible to what metabolic pathway?
A) Aromatic hydroxylation
B) Methylation
C) Sulfate conjugation
D) Oxidative deamination
E) GSH conjugation - answer>>>A) Aromatic hydroxylation
For numbers 24-26, refer to the general structure of penicillin
24. Which of the following will confer resistance against beta lactamases when synthesizing
analogs of penicillin?
A) Halogens
B) Ring deactivators
C) Electron withdrawing group
