Immunology BOC Questions with answers |\ |\ |\ |\
The air temperature throughout the serology laboratory is 20°C.
|\ |\ |\ |\ |\ |\ |\ |\ |\
How will this affect VDRL and RPR test results?
|\ |\ |\ |\ |\ |\ |\ |\
A.no effect—the acceptable test range is 20-24°C
|\ |\ |\ |\ |\ |\
B.weaken reactions so that false-negatives occur
|\ |\ |\ |\ |\
C.strengthen reactions so that positive titers appear elevated
|\ |\ |\ |\ |\ |\ |\
D.increase the number of false-positives from spontaneous
|\ |\ |\ |\ |\ |\ |\
clumping
B.weaken reactions so that false-negatives occur
|\ |\ |\ |\ |\
The immunoglobulin class typically found to be present in saliva,
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
tears and other secretions is:
|\ |\ |\ |\
A.IgG
B.IgA
C.IgM
D.IgD
B.IgA
A 16-year-old boy with infectious mononucleosis has a cold
|\ |\ |\ |\ |\ |\ |\ |\ |\
agglutinin titer of 1:2000. An important consideration of this
|\ |\ |\ |\ |\ |\ |\ |\ |\
antibody's clinical relevance is the: |\ |\ |\ |\
A.thermal range |\
B.titer at 4°C |\ |\
C.specificity
D.light chain type |\ |\
,A.thermal range (It is important to determine the thermal range
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
of reactivity, because cold antibodies are most likely to cause
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
disease if they react with red blood cells at temperatures from
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
30-32°C.)
Antibodies to which of the following immunoglobulins is known to
|\ |\ |\ |\ |\ |\ |\ |\ |\
have produced anaphylactic reactions following blood
|\ |\ |\ |\ |\ |\ |\
transfusion?
A.IgA
B.IgD
C.IgE
D.IgG
A.IgA
The serum hemolytic complement level (CH50):
|\ |\ |\ |\ |\
A.is a measure of total complement activity
|\ |\ |\ |\ |\ |\
B.provides the same information as a serum factor B level
|\ |\ |\ |\ |\ |\ |\ |\ |\
C.is detectable when any component of the classical system is
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
congenitally absent |\
D.can be calculated from the serum concentrations of the
|\ |\ |\ |\ |\ |\ |\ |\ |\
individual components |\
A.is a measure of total complement activity
|\ |\ |\ |\ |\ |\
Delayed hypersensitivity may be induced by:
|\ |\ |\ |\ |\
A.contact sensitivity to inorganic chemicals
|\ |\ |\ |\
B.transfusion reaction |\
C.anaphylactic reaction |\
D.bacterial septicemia |\
A.contact sensitivity to inorganic chemicals
|\ |\ |\ |\
,The disappearance of HBsAg and HBeAg, the persistence of anti-
|\ |\ |\ |\ |\ |\ |\ |\ |\
HBc, the appearance of anti-HBs, and often of anti-HBe indicate:
|\ |\ |\ |\ |\ |\ |\ |\ |\
A.early acute HBV hepatitis |\ |\ |\
B.early convalescent phase HBV hepatitis
|\ |\ |\ |\
C.recovery phase of acute HBV hepatitis |\ |\ |\ |\ |\
D.carrier state of acute HBV hepatitis
|\ |\ |\ |\ |\
C.recovery phase of acute HBV hepatitis (Anti-HBs and anti-HBe
|\ |\ |\ |\ |\ |\ |\ |\ |\
are associated with recovery and development of immunity in
|\ |\ |\ |\ |\ |\ |\ |\ |\
hepatitis B, while HBsAg and HBeAg are antigens from HBV that
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
are present during the infectious stages of disease.)
|\ |\ |\ |\ |\ |\ |\
Immunoediting describes the theory that our immune system |\ |\ |\ |\ |\ |\ |\ |\
prevents many cancers. Its three phases (called the 3 ‘e's)
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
include all of the following EXCEPT:
|\ |\ |\ |\ |\
A.efficiency
B.equilibrium
C.escape
D.elimination
A.efficiency
IgM antibodies are frequently hemolytic because of:
|\ |\ |\ |\ |\ |\
A.their dimeric structure |\ |\
B.the molecule's 5 antigen-binding sites
|\ |\ |\ |\
C.their sedimentation coefficient of 7-15 S
|\ |\ |\ |\ |\
D.their efficient ability to fix complement
|\ |\ |\ |\ |\
D.their efficient ability to fix complement
|\ |\ |\ |\ |\
Skin, lactic acid in sweat, pH balance, mucous, and the motion of
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
cilia represent which type of immunity?
|\ |\ |\ |\ |\ |\
, A.natural
B.acquired
C.adaptive
D.auto
A.natural
The key structural difference that distinguishes immunoglobulin
|\ |\ |\ |\ |\ |\ |\
subclasses is the: |\ |\
A.number of domains |\ |\
B.stereometry of the hypervariable region |\ |\ |\ |\
C.the sequence of the constant regions
|\ |\ |\ |\ |\
D.covalent linkage of the light chains |\ |\ |\ |\ |\
C.the sequence of the constant regions (Immunoglobulin
|\ |\ |\ |\ |\ |\ |\
subclasses differ from each other in their Fc regions; this is the
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
reason that the different classes have different biological
|\ |\ |\ |\ |\ |\ |\ |\
function. The Fc region is the region that is crystallizable after
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
papain cleavage. It varies in sequence in the different classes of
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
immunoglobulin.)
Incompatibility by which of the following procedures is an |\ |\ |\ |\ |\ |\ |\ |\ |\
absolute contraindication to allotransplantation?
|\ |\ |\
A.MLC (mixed lymphocyte culture)
|\ |\ |\
B.HLA typing |\
C.Rh typing|\
D.ABO grouping |\
D.ABO grouping |\
A suspected anthrax lesion was submitted to the lab for
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
preparation and testing. The test of choice to interrogate this
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
sample is: |\
The air temperature throughout the serology laboratory is 20°C.
|\ |\ |\ |\ |\ |\ |\ |\ |\
How will this affect VDRL and RPR test results?
|\ |\ |\ |\ |\ |\ |\ |\
A.no effect—the acceptable test range is 20-24°C
|\ |\ |\ |\ |\ |\
B.weaken reactions so that false-negatives occur
|\ |\ |\ |\ |\
C.strengthen reactions so that positive titers appear elevated
|\ |\ |\ |\ |\ |\ |\
D.increase the number of false-positives from spontaneous
|\ |\ |\ |\ |\ |\ |\
clumping
B.weaken reactions so that false-negatives occur
|\ |\ |\ |\ |\
The immunoglobulin class typically found to be present in saliva,
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
tears and other secretions is:
|\ |\ |\ |\
A.IgG
B.IgA
C.IgM
D.IgD
B.IgA
A 16-year-old boy with infectious mononucleosis has a cold
|\ |\ |\ |\ |\ |\ |\ |\ |\
agglutinin titer of 1:2000. An important consideration of this
|\ |\ |\ |\ |\ |\ |\ |\ |\
antibody's clinical relevance is the: |\ |\ |\ |\
A.thermal range |\
B.titer at 4°C |\ |\
C.specificity
D.light chain type |\ |\
,A.thermal range (It is important to determine the thermal range
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
of reactivity, because cold antibodies are most likely to cause
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
disease if they react with red blood cells at temperatures from
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
30-32°C.)
Antibodies to which of the following immunoglobulins is known to
|\ |\ |\ |\ |\ |\ |\ |\ |\
have produced anaphylactic reactions following blood
|\ |\ |\ |\ |\ |\ |\
transfusion?
A.IgA
B.IgD
C.IgE
D.IgG
A.IgA
The serum hemolytic complement level (CH50):
|\ |\ |\ |\ |\
A.is a measure of total complement activity
|\ |\ |\ |\ |\ |\
B.provides the same information as a serum factor B level
|\ |\ |\ |\ |\ |\ |\ |\ |\
C.is detectable when any component of the classical system is
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
congenitally absent |\
D.can be calculated from the serum concentrations of the
|\ |\ |\ |\ |\ |\ |\ |\ |\
individual components |\
A.is a measure of total complement activity
|\ |\ |\ |\ |\ |\
Delayed hypersensitivity may be induced by:
|\ |\ |\ |\ |\
A.contact sensitivity to inorganic chemicals
|\ |\ |\ |\
B.transfusion reaction |\
C.anaphylactic reaction |\
D.bacterial septicemia |\
A.contact sensitivity to inorganic chemicals
|\ |\ |\ |\
,The disappearance of HBsAg and HBeAg, the persistence of anti-
|\ |\ |\ |\ |\ |\ |\ |\ |\
HBc, the appearance of anti-HBs, and often of anti-HBe indicate:
|\ |\ |\ |\ |\ |\ |\ |\ |\
A.early acute HBV hepatitis |\ |\ |\
B.early convalescent phase HBV hepatitis
|\ |\ |\ |\
C.recovery phase of acute HBV hepatitis |\ |\ |\ |\ |\
D.carrier state of acute HBV hepatitis
|\ |\ |\ |\ |\
C.recovery phase of acute HBV hepatitis (Anti-HBs and anti-HBe
|\ |\ |\ |\ |\ |\ |\ |\ |\
are associated with recovery and development of immunity in
|\ |\ |\ |\ |\ |\ |\ |\ |\
hepatitis B, while HBsAg and HBeAg are antigens from HBV that
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
are present during the infectious stages of disease.)
|\ |\ |\ |\ |\ |\ |\
Immunoediting describes the theory that our immune system |\ |\ |\ |\ |\ |\ |\ |\
prevents many cancers. Its three phases (called the 3 ‘e's)
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
include all of the following EXCEPT:
|\ |\ |\ |\ |\
A.efficiency
B.equilibrium
C.escape
D.elimination
A.efficiency
IgM antibodies are frequently hemolytic because of:
|\ |\ |\ |\ |\ |\
A.their dimeric structure |\ |\
B.the molecule's 5 antigen-binding sites
|\ |\ |\ |\
C.their sedimentation coefficient of 7-15 S
|\ |\ |\ |\ |\
D.their efficient ability to fix complement
|\ |\ |\ |\ |\
D.their efficient ability to fix complement
|\ |\ |\ |\ |\
Skin, lactic acid in sweat, pH balance, mucous, and the motion of
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
cilia represent which type of immunity?
|\ |\ |\ |\ |\ |\
, A.natural
B.acquired
C.adaptive
D.auto
A.natural
The key structural difference that distinguishes immunoglobulin
|\ |\ |\ |\ |\ |\ |\
subclasses is the: |\ |\
A.number of domains |\ |\
B.stereometry of the hypervariable region |\ |\ |\ |\
C.the sequence of the constant regions
|\ |\ |\ |\ |\
D.covalent linkage of the light chains |\ |\ |\ |\ |\
C.the sequence of the constant regions (Immunoglobulin
|\ |\ |\ |\ |\ |\ |\
subclasses differ from each other in their Fc regions; this is the
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
reason that the different classes have different biological
|\ |\ |\ |\ |\ |\ |\ |\
function. The Fc region is the region that is crystallizable after
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
papain cleavage. It varies in sequence in the different classes of
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
immunoglobulin.)
Incompatibility by which of the following procedures is an |\ |\ |\ |\ |\ |\ |\ |\ |\
absolute contraindication to allotransplantation?
|\ |\ |\
A.MLC (mixed lymphocyte culture)
|\ |\ |\
B.HLA typing |\
C.Rh typing|\
D.ABO grouping |\
D.ABO grouping |\
A suspected anthrax lesion was submitted to the lab for
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
preparation and testing. The test of choice to interrogate this
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
sample is: |\
