COMPLETE NR 507 ADVANCED PATHOPHYSIOLOGY
Midterm REAL EXAM ACCURATE QUESTIONS WITH 100%
RATED CORRECT ANSWERS EXPERT VERIFIED GET IT A+
2025 LATEST UPDATED
What does the innermost layer of the bronchioles contain
columnar epithelial ells and mucus producing goblet cells
What does the outermost layer of the bronchioles contain
smooth muscle cells
what does the outermost layer of the bronchioles do
control the airways ability to constrict and dilate
alveolar hyperinflation
When air is unable to move out of the alveolar like it should due to bronchial walls collapsing around
possible mucus plug thus trapping air inside
how does hyperinflation occur?
the ongoing inflammatory process of asthma produces mucus and pus plug that the bronchial walls
collapse around
Effect of hyperinflation of the alveolar
-expanded thorax and hypercapnia (retention of CO2)
- respiratory acidosis
,What are two anticholinergic drugs used for asthma
tiotropium and ipratropium
What is Asthma?
Chronic disease due to bronchoconstriction and an excessive inflammatory response in the bronchioles
What are 5 s/s of asthma
coughing
wheezing
shortness of breath
rapid breathing
chest tightness
Pathophysiology of asthma (5)
-airway inflammation, bronchial hyper-reactivity and smooth muscle spasm
-excess mucus production and accumulation
-hypertrophy of bronchial smooth muscle
-airflow obstruction
-decreased alveolar ventilation
Bronchioles
smaller passageways that originate from the bronchi that become the alveoli
3 layers of the bronchioles
,innermost layer
middle layer - lamina propria
outermost layer
lamina propria
the middle layer of the bronchioles
structure of the lamina propria
embedded with connective tissue cells and immune cells
purpose of the lamina propria
white blood cells are present to help protect the airways
How does the lamina propria effect the lungs in regards to asthma
the WBCs protective feature goes into overdrive causing an inflammatory response that damages host
tissue
What do anticholinergics do in the lungs?
These drugs block the effects of the parasympathetic nervous system
- increasing bronchodilation
MOA of anticholinergic drugs for asthma
, the parasympathetic system is stimulated by the vagal nerve to release acetylcholine which binds to the
cholinergic receptors of the respiratory tract to cause bronchial constriction = decreased airflow
- blocking the cholinergic receptors prevents acetylcholine binding preventing the bronchial constriction
bronchitis
inflammation of the bronchial tubes
3 characteristics of bronchitis
bronchial inflammation
hypersecretion of mucus
chronic productive cough for at least 3 consecutive months for at least 2 successive years
Perfusion
The supply of oxygen to and removal of wastes from the cells and tissues of the body as a result of the
flow of blood through the capillaries.
results of chronic bronchitis/ low perfusion
cyanosis
right to left shunting
chronic hypoxemia
Why is there cyanosis with chronic bronchitis
there is hypoxia due to unfavorable conditions for gas exchange
Midterm REAL EXAM ACCURATE QUESTIONS WITH 100%
RATED CORRECT ANSWERS EXPERT VERIFIED GET IT A+
2025 LATEST UPDATED
What does the innermost layer of the bronchioles contain
columnar epithelial ells and mucus producing goblet cells
What does the outermost layer of the bronchioles contain
smooth muscle cells
what does the outermost layer of the bronchioles do
control the airways ability to constrict and dilate
alveolar hyperinflation
When air is unable to move out of the alveolar like it should due to bronchial walls collapsing around
possible mucus plug thus trapping air inside
how does hyperinflation occur?
the ongoing inflammatory process of asthma produces mucus and pus plug that the bronchial walls
collapse around
Effect of hyperinflation of the alveolar
-expanded thorax and hypercapnia (retention of CO2)
- respiratory acidosis
,What are two anticholinergic drugs used for asthma
tiotropium and ipratropium
What is Asthma?
Chronic disease due to bronchoconstriction and an excessive inflammatory response in the bronchioles
What are 5 s/s of asthma
coughing
wheezing
shortness of breath
rapid breathing
chest tightness
Pathophysiology of asthma (5)
-airway inflammation, bronchial hyper-reactivity and smooth muscle spasm
-excess mucus production and accumulation
-hypertrophy of bronchial smooth muscle
-airflow obstruction
-decreased alveolar ventilation
Bronchioles
smaller passageways that originate from the bronchi that become the alveoli
3 layers of the bronchioles
,innermost layer
middle layer - lamina propria
outermost layer
lamina propria
the middle layer of the bronchioles
structure of the lamina propria
embedded with connective tissue cells and immune cells
purpose of the lamina propria
white blood cells are present to help protect the airways
How does the lamina propria effect the lungs in regards to asthma
the WBCs protective feature goes into overdrive causing an inflammatory response that damages host
tissue
What do anticholinergics do in the lungs?
These drugs block the effects of the parasympathetic nervous system
- increasing bronchodilation
MOA of anticholinergic drugs for asthma
, the parasympathetic system is stimulated by the vagal nerve to release acetylcholine which binds to the
cholinergic receptors of the respiratory tract to cause bronchial constriction = decreased airflow
- blocking the cholinergic receptors prevents acetylcholine binding preventing the bronchial constriction
bronchitis
inflammation of the bronchial tubes
3 characteristics of bronchitis
bronchial inflammation
hypersecretion of mucus
chronic productive cough for at least 3 consecutive months for at least 2 successive years
Perfusion
The supply of oxygen to and removal of wastes from the cells and tissues of the body as a result of the
flow of blood through the capillaries.
results of chronic bronchitis/ low perfusion
cyanosis
right to left shunting
chronic hypoxemia
Why is there cyanosis with chronic bronchitis
there is hypoxia due to unfavorable conditions for gas exchange
