NEW PEDIATRIC COMAT (2025/2026) ACTUAL
EXAM ALL COMPLETE QUESTIONS WITH
DETAILED CORRECT ANSWERS EXPERT VERIFIED
Page | 1
FOR GUARANTEED PASS|TOP RATED A+.
PEDIATRIC COMAT
Pass the Pediatric COMAT Exam 2025/2026 with confidence. This exam
resource features questions in areas like: growth and development, pediatric
illnesses, preventive care, pharmacology, and clinical decision-making. Best
ideal to medical students, particularly those in osteopathic programs, during
their pediatric clinical rotation.
An infant with cleft lip and palate, wide anterior fontanelle, distal
phalange hypoplasia, microcephaly, and cardiac anomalies was likely
exposed to what in utero? ..... ANSWER ...... antiepileptic
medications (ex. phenytoin, valproate)
exposure results in fetal hydantoin syndrome
How should women who take antiepileptics be managed during
pregnancy? ..... ANSWER ...... to avoid fetal hydantoin syndrome,
meds should be titrated to the lowest dose prior to conception and start
them on high dose folic acid supplementation
T/F: cocaine use during pregnancy is not associated with congenital
defects ..... ANSWER ...... True - but it can cause preterm delivery,
placental abruption, and fetal growth restriction
, Use of lisinopril during pregnancy can cause what fetal complications?
..... ANSWER ...... fetal renal failure and associated oligohydramnios
resulting in pulmonary hypoplasia, growth restriction, and limb defects
Page | 2
T/F: fetal alcohol syndrome can present with microcephaly, midfacial
hypoplasia, and cleft lip ..... ANSWER ...... False - it can present
with the first two but it's not associated with cleft lip or palate
What GI infection can mimic appendicitis? What are the two most
common causative agents? ..... ANSWER ...... infectious ileocecitis
aka pseudoappendicitis
T/F: fever rarely occurs with an E coli 0157:H7 infection ..... ANSWER
...... True
The presentation of vulvar pruritis and fusing of the posterior labia
minora is an indication for what treatment? ..... ANSWER ......
topical estrogen cream
Labial adhesion is caused by low estrogen production
In a pediatric patient with suspected acute ischemic stroke, what test
should be urgently performed? ..... ANSWER ...... MR with
angiography
What is Todd paralysis? ..... ANSWER ...... Transient focal deficits
following a seizure
, Infants should gain approximately [grams/oz] per day for the first 3
months ..... ANSWER ...... 30 grams/1 oz per day for first 3 months
Page | 3
A baby should double their birth weight by [age] and triple it by [age]
..... ANSWER ...... double it by 4 months, triple is by 12 months
Height increases by [%] by 12 months of age ..... ANSWER ...... 50%
Patient presenting with bone pain and pancytopenia is concerning for
what? ..... ANSWER ...... acute lymphoblastic leukemia (ALL)
the rampant growth of leukemic cells in the bone marrow can result in
bone pain, classically in the long bones
Note: leukocytes may be increased or decreased, you're looking for at
least 2 cytopenias
What is the most common malignancy in children? ..... ANSWER ......
acute lymphoblastic leukemia (ALL)
A patient experiencing fever, urticarial rash, and arthralgia 5-10 days after
starting penicillin is likely experiencing what? ..... ANSWER ......
serum sickness-like reaction (SSLR)
A nuclear scintigraphy with technetium 99m pertechnetate would be used
to evaluate what potential cause of iron deficiency anemia? .....
ANSWER ...... Meckel diverticulum
, What causes Meckel diverticulum? ..... ANSWER ...... failed closure
of the vitelline duct
Page | 4
How does tumor lysis syndrome cause acute kidney injury? .....
ANSWER ...... excess phosphate and uric acid results in calcium
phosphate stones and uric acid stones which cause obstructions in the
renal tubules
In a patient with a history of recurrent pulmonary and cutaneous
abscesses, an abscess showing organism-filled neutrophils on Gram stain
would be suggestive of what immunodeficiency syndrome? .....
ANSWER ...... chronic granulomatous disease
impaired phagocytic respiratory burst results in impaired intracellular
killing by phagocytes
Patients with chronic granulomatous disease are classically susceptible to
which organisms? ..... ANSWER ...... catalase-positive organisms
(ex. staph aureus, nocardia, aspergillus)
How is chronic granulomatous disease diagnosed? ..... ANSWER ......
testing neutrophil oxidative burst on dihydrorhodamine (DHR) 123 or
nitroblue tetrazolium test
Magical thinking is a normal phase of cognitive development in children
at what age? ..... ANSWER ...... age 2-7
EXAM ALL COMPLETE QUESTIONS WITH
DETAILED CORRECT ANSWERS EXPERT VERIFIED
Page | 1
FOR GUARANTEED PASS|TOP RATED A+.
PEDIATRIC COMAT
Pass the Pediatric COMAT Exam 2025/2026 with confidence. This exam
resource features questions in areas like: growth and development, pediatric
illnesses, preventive care, pharmacology, and clinical decision-making. Best
ideal to medical students, particularly those in osteopathic programs, during
their pediatric clinical rotation.
An infant with cleft lip and palate, wide anterior fontanelle, distal
phalange hypoplasia, microcephaly, and cardiac anomalies was likely
exposed to what in utero? ..... ANSWER ...... antiepileptic
medications (ex. phenytoin, valproate)
exposure results in fetal hydantoin syndrome
How should women who take antiepileptics be managed during
pregnancy? ..... ANSWER ...... to avoid fetal hydantoin syndrome,
meds should be titrated to the lowest dose prior to conception and start
them on high dose folic acid supplementation
T/F: cocaine use during pregnancy is not associated with congenital
defects ..... ANSWER ...... True - but it can cause preterm delivery,
placental abruption, and fetal growth restriction
, Use of lisinopril during pregnancy can cause what fetal complications?
..... ANSWER ...... fetal renal failure and associated oligohydramnios
resulting in pulmonary hypoplasia, growth restriction, and limb defects
Page | 2
T/F: fetal alcohol syndrome can present with microcephaly, midfacial
hypoplasia, and cleft lip ..... ANSWER ...... False - it can present
with the first two but it's not associated with cleft lip or palate
What GI infection can mimic appendicitis? What are the two most
common causative agents? ..... ANSWER ...... infectious ileocecitis
aka pseudoappendicitis
T/F: fever rarely occurs with an E coli 0157:H7 infection ..... ANSWER
...... True
The presentation of vulvar pruritis and fusing of the posterior labia
minora is an indication for what treatment? ..... ANSWER ......
topical estrogen cream
Labial adhesion is caused by low estrogen production
In a pediatric patient with suspected acute ischemic stroke, what test
should be urgently performed? ..... ANSWER ...... MR with
angiography
What is Todd paralysis? ..... ANSWER ...... Transient focal deficits
following a seizure
, Infants should gain approximately [grams/oz] per day for the first 3
months ..... ANSWER ...... 30 grams/1 oz per day for first 3 months
Page | 3
A baby should double their birth weight by [age] and triple it by [age]
..... ANSWER ...... double it by 4 months, triple is by 12 months
Height increases by [%] by 12 months of age ..... ANSWER ...... 50%
Patient presenting with bone pain and pancytopenia is concerning for
what? ..... ANSWER ...... acute lymphoblastic leukemia (ALL)
the rampant growth of leukemic cells in the bone marrow can result in
bone pain, classically in the long bones
Note: leukocytes may be increased or decreased, you're looking for at
least 2 cytopenias
What is the most common malignancy in children? ..... ANSWER ......
acute lymphoblastic leukemia (ALL)
A patient experiencing fever, urticarial rash, and arthralgia 5-10 days after
starting penicillin is likely experiencing what? ..... ANSWER ......
serum sickness-like reaction (SSLR)
A nuclear scintigraphy with technetium 99m pertechnetate would be used
to evaluate what potential cause of iron deficiency anemia? .....
ANSWER ...... Meckel diverticulum
, What causes Meckel diverticulum? ..... ANSWER ...... failed closure
of the vitelline duct
Page | 4
How does tumor lysis syndrome cause acute kidney injury? .....
ANSWER ...... excess phosphate and uric acid results in calcium
phosphate stones and uric acid stones which cause obstructions in the
renal tubules
In a patient with a history of recurrent pulmonary and cutaneous
abscesses, an abscess showing organism-filled neutrophils on Gram stain
would be suggestive of what immunodeficiency syndrome? .....
ANSWER ...... chronic granulomatous disease
impaired phagocytic respiratory burst results in impaired intracellular
killing by phagocytes
Patients with chronic granulomatous disease are classically susceptible to
which organisms? ..... ANSWER ...... catalase-positive organisms
(ex. staph aureus, nocardia, aspergillus)
How is chronic granulomatous disease diagnosed? ..... ANSWER ......
testing neutrophil oxidative burst on dihydrorhodamine (DHR) 123 or
nitroblue tetrazolium test
Magical thinking is a normal phase of cognitive development in children
at what age? ..... ANSWER ...... age 2-7
