GCU NUR 635 MIDTERM COMPLETE
EXAMINATION, QUESTIONS WITH CORRECT AND
ONLY ANSWERS
absorption, distribution, metabolism, elimination - answer ✔✔-Pharmacokinetics includes
PH changes, gastric emptying, gastric enzymes, bile acids, GI flora, food and nutrient interactions, lipid
solubility - answer ✔✔-absorption of drugs factors
endoplasmic reticulum of hepatocytes - answer ✔✔-Where is cyp450 system found
most abundant CYP450 isoform which metabolizes the most prescribed
" "drugs. Especially important for bioavailability due to its abundance in
" "cells lining the GI tract. Can be induced by a wide variety of drugs "
"and is potently inhibited by ketoconazole and erythromycin. - answer ✔✔-CYP3A4/5
metabolizes 25% of prescribed drugs
*3*4*5 majority of bad metabolizers
Antidepressants
Antipsychotics
Antiarrythmics
*carvedilol, *metoprolol
*codeine → morphine
*tamoxifen to active - answer ✔✔-CYP2D6
warfarin - answer ✔✔-CYP2c8/9
, AcetAminophen - answer ✔✔-CYP1A2
carbamazepine, rifampin,
alcohol, phenytoin, griseofulun, phenobarbitone, sulfonylureas - answer ✔✔-CRAP GPS induces my rage
variable and erratic - answer ✔✔-rectal admin has what absorption
4-5 - answer ✔✔-steady state (SS) is usually reached within how many half-lives of a drug
at a constant rate per unit time - answer ✔✔-zero-order(nonlinear) pharmacokinetics means a drug is
metabolized
the rate of drug elimination is directly proportion to the concentration of free drug (phenytoin) - answer
✔✔-Michaelis-menten pharmacokinetics
TD50 = median toxic dose
ED50 = median effective dose
window = between those doses
safe drugs have a wider or high window/index - answer ✔✔-theraputic index
drugs that alter the physiology of a cell by binding to plasma membrane or intracellular receptors -
answer ✔✔-Agonist
These drugs block the actions caused by agonists - answer ✔✔-Antagonists (drugs)
a drug can be used for an unapproved indication and is legitimate if there is clinical data supporting its
use for that indication - answer ✔✔-off-label use
EXAMINATION, QUESTIONS WITH CORRECT AND
ONLY ANSWERS
absorption, distribution, metabolism, elimination - answer ✔✔-Pharmacokinetics includes
PH changes, gastric emptying, gastric enzymes, bile acids, GI flora, food and nutrient interactions, lipid
solubility - answer ✔✔-absorption of drugs factors
endoplasmic reticulum of hepatocytes - answer ✔✔-Where is cyp450 system found
most abundant CYP450 isoform which metabolizes the most prescribed
" "drugs. Especially important for bioavailability due to its abundance in
" "cells lining the GI tract. Can be induced by a wide variety of drugs "
"and is potently inhibited by ketoconazole and erythromycin. - answer ✔✔-CYP3A4/5
metabolizes 25% of prescribed drugs
*3*4*5 majority of bad metabolizers
Antidepressants
Antipsychotics
Antiarrythmics
*carvedilol, *metoprolol
*codeine → morphine
*tamoxifen to active - answer ✔✔-CYP2D6
warfarin - answer ✔✔-CYP2c8/9
, AcetAminophen - answer ✔✔-CYP1A2
carbamazepine, rifampin,
alcohol, phenytoin, griseofulun, phenobarbitone, sulfonylureas - answer ✔✔-CRAP GPS induces my rage
variable and erratic - answer ✔✔-rectal admin has what absorption
4-5 - answer ✔✔-steady state (SS) is usually reached within how many half-lives of a drug
at a constant rate per unit time - answer ✔✔-zero-order(nonlinear) pharmacokinetics means a drug is
metabolized
the rate of drug elimination is directly proportion to the concentration of free drug (phenytoin) - answer
✔✔-Michaelis-menten pharmacokinetics
TD50 = median toxic dose
ED50 = median effective dose
window = between those doses
safe drugs have a wider or high window/index - answer ✔✔-theraputic index
drugs that alter the physiology of a cell by binding to plasma membrane or intracellular receptors -
answer ✔✔-Agonist
These drugs block the actions caused by agonists - answer ✔✔-Antagonists (drugs)
a drug can be used for an unapproved indication and is legitimate if there is clinical data supporting its
use for that indication - answer ✔✔-off-label use
