Pharm II Heart failure Exam
1. negative inotropes that worsen HF: beta blockers
non-DHP CCB
itraconazole
2. medications that cause sodium and water retention that worsen HF: NSAIDS
cox 2 inhibitors
glucocorticoids
androgens/estrogens
rosiglitazone/pioglitazone
3. cardiotoxic meds that worsen HF: anthracyclins- doxorubicin, daunomycin
ethanol
4. SGLT2 inhibitors MOA: reduce reabsorption of glucose and sodium in the proximal renal tubules which
leads to glucose and sodium excretion in the urine = decreased preload and after load
5. SGLT2 inhibitors are indicated in HF when: pt has HFrEF (decreases CV death and hospitaliza-
tion)
1/4
, 6. name the SGLT2 inhibitors: dapagliflozin
empagliflozin
7. sacubitril/valsartan (entresto) is an: ARNI
8. sacubitril/valsartan (entresto) is used for HF when: HFrEF and NYHA II/III
9. if pt cannot tolerate ARNI what is second line medication: ACEi or ARB
10. net effect of an ARNI: increase natriuretic peptides that decrease blood volume and preload
11. sacubitril must be used in conjunction with an: ARB
sacubitril = neprilysin inhbitior, when neprilysin inhibited angiotensin II accumulates
ARB blocks effects of excess angiotensin II
12. monitoring for ARNI: K
renal function
blood pressure
13. ARNI should not be administered with: ACEi
within 36 hours of last dose of ACEi
2/4
1. negative inotropes that worsen HF: beta blockers
non-DHP CCB
itraconazole
2. medications that cause sodium and water retention that worsen HF: NSAIDS
cox 2 inhibitors
glucocorticoids
androgens/estrogens
rosiglitazone/pioglitazone
3. cardiotoxic meds that worsen HF: anthracyclins- doxorubicin, daunomycin
ethanol
4. SGLT2 inhibitors MOA: reduce reabsorption of glucose and sodium in the proximal renal tubules which
leads to glucose and sodium excretion in the urine = decreased preload and after load
5. SGLT2 inhibitors are indicated in HF when: pt has HFrEF (decreases CV death and hospitaliza-
tion)
1/4
, 6. name the SGLT2 inhibitors: dapagliflozin
empagliflozin
7. sacubitril/valsartan (entresto) is an: ARNI
8. sacubitril/valsartan (entresto) is used for HF when: HFrEF and NYHA II/III
9. if pt cannot tolerate ARNI what is second line medication: ACEi or ARB
10. net effect of an ARNI: increase natriuretic peptides that decrease blood volume and preload
11. sacubitril must be used in conjunction with an: ARB
sacubitril = neprilysin inhbitior, when neprilysin inhibited angiotensin II accumulates
ARB blocks effects of excess angiotensin II
12. monitoring for ARNI: K
renal function
blood pressure
13. ARNI should not be administered with: ACEi
within 36 hours of last dose of ACEi
2/4
