PATH 370 WEEK 2 EXAM QUESTIONS WITH
COMPLETE DETAILED ANSWERS
chronic myeloid leukemia clinical significance - answer ✔✔-presence of philadelphia chromosome
high granulocyte count
CML stats - answer ✔✔-15% of all leukemia cases
avg age: 40-45
CML signs/symptoms - answer ✔✔-fatigue, weight loss, sweats, bleeding disorder, splenomegaly
CML treatment - answer ✔✔-responds poorly to chemo
anti bcr/abl therapy
bmt (bone marrow transfusion)
what happens if CML left untreated? - answer ✔✔-median survival ~2 years
acute myeloid luekemia significance? - answer ✔✔-malignant disorder associated with transformation
of myeloid stem cells
cells have large segmented nucleus + fine chromatin
increase infection susceptibility (skin, GI, GU, respiratory)
AML stats - answer ✔✔-80% all cases are adults
avg age: 64
AML signs/symptoms - answer ✔✔-anemia, bone pain, thrombocytopenia
, AML treatment goals - answer ✔✔-incorportate cytogenic profile of leukemic cells to individualized
therapy and monitor response
AML treatment phases (2) - answer ✔✔-phase 1: remission induction-attempt chemo
phase 2: post remission- attempt elimination of any undetected residual leukemic cells
chronic lymphoid leukemia clinical signs - answer ✔✔-increased infection susceptibility, defective
apoptosis (CLL longer life span)
reduced RBC, platelets
CLL symptoms/signs - answer ✔✔-weight loss, anorexia, lymphadenopathy, fatigue, splenomegaly
CLL treatment - answer ✔✔-depends-
rapid growth: chemo
no response: stem cell transplant
acute lymphoblastic leukemia general stats - answer ✔✔-80% malignant B cells, 20% malignant T cells
peak b/w 3-7 years old, second peak b/w middle age
primarily children's disease
ALL clinical significance - answer ✔✔-2nd leading cause of children's disease
abrupt onset of symptoms, refusal to walk, 3% signs of CNS, increase infection suseptibility
ALL signs/symptoms - answer ✔✔-bone pain, bruising,enlarged liver fever, fatigue, loss appetite,
splenomegaly, lymphadenopathy,
ALL treatment - answer ✔✔-chemo for induction and post remission
90% cure rate for pre B cell malignancy
COMPLETE DETAILED ANSWERS
chronic myeloid leukemia clinical significance - answer ✔✔-presence of philadelphia chromosome
high granulocyte count
CML stats - answer ✔✔-15% of all leukemia cases
avg age: 40-45
CML signs/symptoms - answer ✔✔-fatigue, weight loss, sweats, bleeding disorder, splenomegaly
CML treatment - answer ✔✔-responds poorly to chemo
anti bcr/abl therapy
bmt (bone marrow transfusion)
what happens if CML left untreated? - answer ✔✔-median survival ~2 years
acute myeloid luekemia significance? - answer ✔✔-malignant disorder associated with transformation
of myeloid stem cells
cells have large segmented nucleus + fine chromatin
increase infection susceptibility (skin, GI, GU, respiratory)
AML stats - answer ✔✔-80% all cases are adults
avg age: 64
AML signs/symptoms - answer ✔✔-anemia, bone pain, thrombocytopenia
, AML treatment goals - answer ✔✔-incorportate cytogenic profile of leukemic cells to individualized
therapy and monitor response
AML treatment phases (2) - answer ✔✔-phase 1: remission induction-attempt chemo
phase 2: post remission- attempt elimination of any undetected residual leukemic cells
chronic lymphoid leukemia clinical signs - answer ✔✔-increased infection susceptibility, defective
apoptosis (CLL longer life span)
reduced RBC, platelets
CLL symptoms/signs - answer ✔✔-weight loss, anorexia, lymphadenopathy, fatigue, splenomegaly
CLL treatment - answer ✔✔-depends-
rapid growth: chemo
no response: stem cell transplant
acute lymphoblastic leukemia general stats - answer ✔✔-80% malignant B cells, 20% malignant T cells
peak b/w 3-7 years old, second peak b/w middle age
primarily children's disease
ALL clinical significance - answer ✔✔-2nd leading cause of children's disease
abrupt onset of symptoms, refusal to walk, 3% signs of CNS, increase infection suseptibility
ALL signs/symptoms - answer ✔✔-bone pain, bruising,enlarged liver fever, fatigue, loss appetite,
splenomegaly, lymphadenopathy,
ALL treatment - answer ✔✔-chemo for induction and post remission
90% cure rate for pre B cell malignancy
