Summary Pathogenesis of the Radicular Cyst

PATHOPHYSIOLOGY OF THE
RADICULAR CYST

A TOOTH IS SUBJECTED TO CARIES/TRAUMA

THE BACTERIA FROM THE CARIES CAUSES
IRREVERSIBLE PULPITIS. IF LEFT UNTREATED, THE
TOOTH GOES NECROTIC.




BACTERIA WITH ENDOTOXIN




BACTERIA SPREADS DOWN THE
ROOT CANAL AND REACHES THE
PERIAPICAL BONE TO FORM A
GRANULOMA

BACTERIA AND THEIR TOXINS EXIT THE ROOT
CANAL SYSTEM THROUGH THE APICAL
FORAMEN INTO THE SURROUNDING BONE. THIS
CAUSES AN INFLAMMATORY RESPONSE
CAUSING MIGRATION OF PLASMA CELLS &
MACROPHAGES TO THE AREA FORMING A
GRANULOMA ( <10MM DIAMETER)




ALVEOLAR BONE

PLASMA CELLS & MACROPHAGES

, PATHOPHYSIOLOGY OF THE
RADICULAR CYST



CELL RESTS OF MALASSEZ ARE STIMULATED

PERSISTENCE OF INFECTION IN THE PERIAPICAL ZONE
STIMULATES CELL RESTS PF MALASSEZ IN THE PDL VIA
INTERLEUKIN 1 AND INTERLEUKIN 6. THESE CELLS PROLIFERATE
AND BEGIN THE FOUNDATION OF THE RADICULAR CYST LINING




CELL RESTS OF MALASSEZ
PROLIFERATE


THE PERIAPICAL GRANULOMA
PERSISTS