CSO Exam -- Appendix 8 -- Drug,
Nutrient, Food, and Dietary Supplement
Interactions with Cancer Meds Exam
2026 Questions and Answers
Axitinib/Inlyta
Take 2x/day -- 12 hours apart - Correct answer-Grapefruit juice + Ketoconazole +
Erythromycin may increase drug activity (CYP34A inducers)
St. John's Wort + Phenobarbitoal may decrease drug activity (CYP3A4 Inhibitors)
Baxarotene/Targretin
Take 1x/day w/ food - Correct answer-Grapefruit juice = may increase [ ] +
toxicities
Limit Vit A to <1500 IU/day as possible toxicities
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,Bortezomin/Velcade
IV or SC - Correct answer-NO Green tea, especially if liquid/capsule form
CYP3A4 inhibitors/inducers may affect
Busulfan/Myleron
Take on empty stomach - Correct answer-NO aspirin OTC
Capecitabine/Xeloda
w/in 30 min of po + glass water - Correct answer-monitor if taking
warfarin/clotting
vit B6 (50 mg-100 mg BID-TID) to prevent/reduce hand-foot syndrome severity
Cetuximab/Erbitux
IV - Correct answer-Monitor: serum Mg, serum Ca ----> those at risk: elderly,
hypomagnesemia @ baseline, prior tx w/ oxaliplatin
Chlorambucil/Leukeran
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, Empty stomach (1 hr prior or 2 hr s/p meal times) - Correct answer-Inc risk
toxicity if barbiturates have been taken (ex: phenobarbital)
Cisplatin/Platinol
IV - Correct answer-Rigours hydration to prevent nephrotoxicity ---> monitor
BUN, Cr, mg, ca, na, k --> at risk: elderly, hypomag @ baseline, impaired renal fxn
@ baseline
Cyclophosphamide/Cytoxan
IV or PO
take early in day w/ vigourous hydration - Correct answer-Vigorous hydration -- at
least 3L/day with frequent empty of bladder q2-3 hours
Mesna given w/ high dose to prevent hemorrhagic cystitis
Increases the effect of anticoagulants
Dasatinib/Sprycel
can take w/ or w/o food - Correct answer-*Do not crush or cut drug*
©COPYRIGHT 2025, ALL RIGHTS RESERVED 3
Nutrient, Food, and Dietary Supplement
Interactions with Cancer Meds Exam
2026 Questions and Answers
Axitinib/Inlyta
Take 2x/day -- 12 hours apart - Correct answer-Grapefruit juice + Ketoconazole +
Erythromycin may increase drug activity (CYP34A inducers)
St. John's Wort + Phenobarbitoal may decrease drug activity (CYP3A4 Inhibitors)
Baxarotene/Targretin
Take 1x/day w/ food - Correct answer-Grapefruit juice = may increase [ ] +
toxicities
Limit Vit A to <1500 IU/day as possible toxicities
©COPYRIGHT 2025, ALL RIGHTS RESERVED 1
,Bortezomin/Velcade
IV or SC - Correct answer-NO Green tea, especially if liquid/capsule form
CYP3A4 inhibitors/inducers may affect
Busulfan/Myleron
Take on empty stomach - Correct answer-NO aspirin OTC
Capecitabine/Xeloda
w/in 30 min of po + glass water - Correct answer-monitor if taking
warfarin/clotting
vit B6 (50 mg-100 mg BID-TID) to prevent/reduce hand-foot syndrome severity
Cetuximab/Erbitux
IV - Correct answer-Monitor: serum Mg, serum Ca ----> those at risk: elderly,
hypomagnesemia @ baseline, prior tx w/ oxaliplatin
Chlorambucil/Leukeran
©COPYRIGHT 2025, ALL RIGHTS RESERVED 2
, Empty stomach (1 hr prior or 2 hr s/p meal times) - Correct answer-Inc risk
toxicity if barbiturates have been taken (ex: phenobarbital)
Cisplatin/Platinol
IV - Correct answer-Rigours hydration to prevent nephrotoxicity ---> monitor
BUN, Cr, mg, ca, na, k --> at risk: elderly, hypomag @ baseline, impaired renal fxn
@ baseline
Cyclophosphamide/Cytoxan
IV or PO
take early in day w/ vigourous hydration - Correct answer-Vigorous hydration -- at
least 3L/day with frequent empty of bladder q2-3 hours
Mesna given w/ high dose to prevent hemorrhagic cystitis
Increases the effect of anticoagulants
Dasatinib/Sprycel
can take w/ or w/o food - Correct answer-*Do not crush or cut drug*
©COPYRIGHT 2025, ALL RIGHTS RESERVED 3
