FOCUS ON NURSING PHARMACOLOGY 9TH
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EDITION BY AMY KARCH CHAPTER 1-
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59 ISBN 13;978-
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1975180409/ISBN 10;1975180402 COMPLETE GU o o o oo
IDE/ GRADED A+
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Chapter 01- Introduction to Drugs
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Aonurseoworkingoinoradiologyoadministersoiodineotooaopatientowhooisohavingoaocomputedotomography(CT)osca
n.oTheonurseoworkingoonotheooncologyounitoadministersochemotherapyotoopatientsowhoohaveocancer
.oAtotheoPublicoHealthoDepartment,oaonurseoadministersoaomeasles-mumps-
rubellao(MMR)ovaccineotooao14-month-
oldochildoasoaoroutineoimmunization.oWhichobranchoofopharmacologyobestodescribesotheoactionsoofo
allothreeonurses?
Pharmacoeconomicso
Pharmacotherapeuticso
PharmacodynamicsoP
harmacokineticsoAns:
B
Feedback:
Pharmacologyoisotheostudyoofotheobiologicoeffectsoofochemicals.oNursesoareoinvolvedowithoclinicalophar
macologyooropharmacotherapeutics,owhichoisoaobranchoofopharmacologyothatodealsowithotheousesoofodrugsotoo
treat,oprevent,oandodiagnoseodisease.oTheoradiologyonurseoisoadministeringoaodrugotoohelpodiagnoseoaodis
ease.oTheooncologyonurseoisoadministeringoaodrugotoohelpotreatoaodisease.
Pharmacoeconomicsoincludesoanyocostsoinvolvedoinodrugotherapy.oPharmacodynamicsoinvolvesohowoao
drugoaffectsotheobodyoandopharmacokineticsoisohowotheobodyoactsoonotheobody.
Aophysicianohasoorderedointramuscularo(IM)oinjectionsoofomorphine,oaonarcotic,oeveryo4ohoursoasoneededforop
ainoinoaomotorovehicleoaccidentovictim.oTheonurseoisoawareothisodrugohasoaohighoabuseopotential.oU
nderowhatocategoryowouldomorphineobeoclassified?
ScheduleoIoS
cheduleoIIoSc
heduleoIIIoSc
heduleoIVoA
ns: B
Feedback:
Narcoticso withoaohighoabuseo potentialo areoclassifiedoasoScheduleoIIodrugso becauseoofosevereo dependence
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liability.oScheduleoIodrugsohaveohighoabuseopotentialoandonooacceptedomedicalouse.oScheduleoIIIodrugsoha
veoaolesseroabuseopotentialothanoIIoandoanoacceptedomedicalouse.oScheduleoIVodrugsohaveolowoabuseopo
tentialoandolimitedodependenceoliability.
WhenoinvolvedoinophaseoIIIodrugoevaluationostudies,owhatoresponsibilitiesowouldotheonurseohave?oW
orkingowithoanimalsowhooareogivenoexperimentalodrugs
ChoosingoappropriateopatientsotoobeoinvolvedoinotheodrugostudyoMo
nitoringoandoobservingopatientsocloselyoforoadverseoeffectsoConducti
ngoresearchotoodetermineoeffectivenessoofotheodrugAns:o C
Feedback:
PhaseoIIIostudiesoinvolveouseoofoaodrugoinoaovastoclinicalopopulationoinowhichopatientsoareoaskedotoorecordoa
nyosymptomsotheyoexperienceowhileotakingotheodrugs.oNursesomayobeoresponsibleoforohelpingocollectoa
ndoanalyzeotheoinformationotoobeosharedowithotheoFoodoandoDrugoAdministrationo(FDA)obutowouldonotoc
onductoresearchoindependentlyobecauseonursesodoonotoprescribeomedications.oUseoofoanimalsoinodrugot
estingoisodoneoinotheopreclinicalotrials.oSelectopatientsowhooareoinvolvedoinophaseoIIostudiesotooparticipateo in
ostudiesowhereotheoparticipants ohaveotheodisease otheodrugoisointended otootreat.oThese opatients oareomonit
oredocloselyoforodrugoactionoandoadverseoeffects.oPhaseoIostudiesoinvolveohealthyohumanovolunteersowhooar
eousuallyopaidoforotheiroparticipation.oNursesomayoobserveoforoadverseoeffectsoandotoxicity.
Whatoconceptoisoconsideredowhenogenericodrugsoareosubstitutedoforobrandonameodrugs?oBioavailabili
ty
Criticaloconcentrationo
Distribution
Half-
lifeoAns: A
Feedback:
Bioavailabilityoisotheoportionoofoaodoseoofoaodrugothatoreachesotheosystemicocirculationoandoisoavailableotooac
toonobodyocells.oBindersousedoinoaogenericodrugomayonotobeotheosameoasothoseousedoinotheobrandonameodr
ug.oTherefore,otheowayotheobodyobreaksodownoandousesotheodrugomayodiffer,owhichomayoeliminateoaoge
nericodrugosubstitution.oCriticaloconcentrationoisotheoamountoofoaodrugothatoisoneededotoocauseoaotherap
euticoeffectoandoshouldonotodifferobetweenogenericoandobrandonameomedications.oDistributionoisotheoph
aseoofopharmacokinetics,owhichoinvolvesotheomovementoofoaodrugotootheobody’sotissuesoandoisothe
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sameoinogenericoandobrandonameodrugs.oAodrug’sohalf-
lifeoisotheotimeoitotakesoforotheoamountoofodrugotoodecreaseotoohalfotheopeakolevel,owhichoshouldonotochang
eowhenosubstitutingoaogenericomedication.
Aonurseoisoassessingotheopatient’sohomeomedicationouse.oAfterolisteningotootheopatientolistocurrentome
dications,otheonurseoasksowhatopriorityoquestion?
Dooyouotakeoanyogenericomedications?
Areoanyo ofotheseo medicationso orphano drugs?
Areotheseomedicationsosafeotootakeoduringopregnancy?o
Dooyouotakeoanyoover-the-counteromedications?
Ans: D
Feedback:
Itoisoimportantoforotheonurseotoospecificallyoquestionouseoofoover-the-
counteromedicationsobecauseopatientsomayonotoconsiderothemoimportant.oTheopatientoisounlikelyotooknowoth
eomeaningoofoorphanodrugsounlessotheyotoooareohealthocareoproviders.oSafetyoduringopregnancy,ouseoofoao
genericomedication,ooroclassificationoofoorphanodrugsoareothingsotheopatientowouldobeounableotooanswero
butocouldobeofoundoinoreferenceobooksoifotheonurseowishesotooresearchothem.
Afterocompletingoaocourseoonopharmacologyoforonurses,owhatowillotheonurseoknow?oEverythin
gonecessaryoforosafeoandoeffectiveomedicationoadministration
Currentopharmacologic otherapy;otheonurseowillonotorequireoongoingoeducationoforo5oyears.o
Generalodrugoinformation;otheonurseocanoconsultoaodrugoguideoforospecificodrugoinformation.oT
heodrugoactionsothatoareoassociatedowithoeachoclassificationoofomedicationAns: C
Feedback:
Afterocompletingoaopharmacologyocourseonursesowillohaveogeneralodrugoinformationoneededoforosafeoandoef
fectiveomedicationoadministrationobutowilloneedotooconsultoaodrugoguideoforospecificodrugoinformationob
eforeoadministeringoanyomedication.oPharmacologyoisoconstantlyochanging,owithonewodrugsoenteringot
heomarketoandonewousesoforoexistingodrugsoidentified.oContinuingoeducationoinopharmacologyoisoessent
ialotoosafeopractice.oNursesotendotoobecomeofamiliarowithotheomedicationsotheyoadministeromostooften,ob
utothereowilloalwaysobeoaoneedotooresearchonewodrugsoandoalsoothoseotheonurseoisonotofamiliarowithobecause
ono onurseoknowsoallomedications.