BIOPHARMACEUTICS AND PHARMACOKINETICS exam questions with answers

BIOPHARMACEUTICS AND |\ |\




PHARMACOKINETICS exam questions |\ |\ |\




with answers |\




It is defined as the release of drug from its dosage form: -
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CORRECT ANSWERS ✔✔Liberation |\ |\




Clinically, GFR is measured using which of the following drugs?
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I. Inulin
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II. Creatinine
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III. Creatine
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IV. Insulin - CORRECT ANSWERS ✔✔I and II
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Which of the following statements best describes F? - CORRECT
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ANSWERS ✔✔Fraction of the administered drug that reaches the
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systemic circulation. |\




If the dose (X0) and AUC are unknown, clearance (area method)
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is calculated by: - CORRECT ANSWERS ✔✔Dose/AUC
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If 500 mg of a drug is given orally and 125 mg is absorbed into
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the systemic circulation, what is F? - CORRECT ANSWERS ✔✔125
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mg/500 mg = 0.25 |\ |\ |\

,For the body fluid compartments below, rank them from the
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lowest volume to the highest, in a typical 70-kg person:
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I. Plasma < extracellular fluid < intracellular < total body water
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II. Total body water < extracellular fluid < intracellular < Plasma
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III. Plasma < Intracellular < Extracellular Fluid < Total body water
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- CORRECT ANSWERS ✔✔I only
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If the VD is approximately 5 liters? - CORRECT ANSWERS ✔✔Drug
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is not well-distributed.
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The superfamily of enzyme responsible for oxidative metabolism
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of drugs during Phase I drug biotransformation:
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I. Mixed Function Oxidases
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II. Mono-oxygenase
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III. CYP450 |\




IV. Hydrogenase - CORRECT ANSWERS ✔✔I, II and III
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Two important routes of drug excretion are: - CORRECT ANSWERS
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✔✔renal and biliary
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What governs the principle of diffusion? - CORRECT ANSWERS
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✔✔Fick's law |\

,Which of the following is not a Phase I reaction? - CORRECT
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ANSWERS ✔✔Glucuronidation |\




Biotransformation may be dependent on factors such as age, |\ |\ |\ |\ |\ |\ |\ |\ |\


____, ______. - CORRECT ANSWERS ✔✔disease and genetics
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The conversion of drug to inactive, polar and non-toxic form is
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called: - CORRECT ANSWERS ✔✔Metabolism
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The body converts a drug to a less active substance by a process
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called: - CORRECT ANSWERS ✔✔Biotransformation
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Which of the following is the best definition of beta (B)? -
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CORRECT ANSWERS ✔✔Terminal Elimination Rate Constant |\ |\ |\ |\ |\




Which is the following plasma proteins and their function is
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correctly matched? |\




I. albumin - acidic drugs
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II. alpha-acid glycoprotein - basic drugs
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III. globulin - hormones - CORRECT ANSWERS ✔✔I, II and III
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The extent to which a drug is absorbed partially determines its: -
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CORRECT ANSWERS ✔✔Bioavailability |\ |\




Biotransformation is also known as: - CORRECT ANSWERS |\ |\ |\ |\ |\ |\ |\ |\


✔✔Metabolism

, Which of the following types of metabolism do drugs with a high
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extraction ratio undergo to a significant extent? - CORRECT
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ANSWERS ✔✔First-pass |\




Because the extraction ratio can maximally be 1, the maximum
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value that hepatic clearance can approach is that of: - CORRECT
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ANSWERS ✔✔Hepatic Blood Flow |\ |\ |\




The study of the time course of drug absorption, distribution,
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metabolism, and excretion is called: - CORRECT ANSWERS |\ |\ |\ |\ |\ |\ |\ |\


✔✔Pharmacokinetics


Enzyme inhibitors: |\




I. Grapefruit juice
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II. St. John's Wort
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III. Macrolides - CORRECT ANSWERS ✔✔I and III
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What are the 2 important physiologic factors affecting
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distribution?


I. Cardiac Output
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II. Regional blood flow
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III. Volume of Distribution - CORRECT ANSWERS ✔✔I and II
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