complete solutions A+ rated
Define bacteriostatic - correct answer ✔✔ Inhibit the growth of bacteria
Define bactericidal - correct answer ✔✔ Rapidly kill the target organism
Define MIC - correct answer ✔✔ Minimum inhibitory concentration - minimum concentration
of the drug necessary to inhibit the growth of the organism.
What is the importance of the MIC test? - correct answer ✔✔ In-vitro test performed to
determine which antimicrobials are most likely to be effective
What are breakpoints? - correct answer ✔✔ known MIC values that have been empirically
determined for a given antimicrobial with a given pathogen in a given animal species.
Define MBC - correct answer ✔✔ Minimum bactericidal concentration - Gives a better
indication of the usefulness of antimicrobials that are bactericidal rather than bacteriostatic.
How is the spectrum of an antimicrobial agent determined? - correct answer ✔✔ Determined
by how wide a variety of bacteria are affected by it.
What does the Kirby-Bauer test? - correct answer ✔✔ This tests if bacteria are susceptible to
certain types of antibodies
What are the different developments of resistance for antimicrobial drugs? - correct answer
✔✔ Spontaneous
, Step-Wise
Transmissible
Spontaneous resistance - correct answer ✔✔ Common largely due to tremendous replication
rates of bacteria
Transmissible resistance - correct answer ✔✔ Genes for resistance reside in the organism
producing an antimicrobial
What are the different groups of antimicrobial agents? - correct answer ✔✔ Inhibition of
growth by analogues, Inhibition of cell wall synthesis, Cell membrane inhibitors, Inhibitors of
DNA synthesis, Inhibition of protein synthesis and assembly: inhibitors of transcription,
translation, 30S ribosomal subunit, 50S ribosomal subunit, Macrolides, and inhibitors of protein
assembly
Extra-label drug use - Ceftiofur, legal or illegal for feed use? - correct answer ✔✔ ILLEGAL
Antimicrobial agents that inhibit growth by analogues - correct answer ✔✔ Sulfonamides
How do sulfonamides work? - correct answer ✔✔ Competitively inhibit the pathway for folic
acid synthesis and prevent the growth of bacteria
Unlike animal cells, many bacteria require what for growth? - correct answer ✔✔ Para
aminobenzoic acid (PABA)
What is PABA used for? - correct answer ✔✔ Used to form folic acid, a necesesary component
for synthesis of purines