UAMS HEMATOLOGY EXAM NEWEST 2025 ACTUAL
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Sickle cell anemia. Hemoglobin S is produced instead of A, due
to valine being substituted for glutamic acid on the 6th position
of the Beta chain. Hemoglobin S aggregates to form a tactoid
structure that forms a sickle shape at low O2 tensions.
.....ANSWER..... What is a chronic hemolytic anemia resulting from
an inherited alteration of the globin chain? What characterizes
it?
Bone marrow. 4% .....ANSWER..... What is one of the largest
organs in the body? What % does it comprise of body weight?
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Posterior superior iliac crest. Sternum, but is more dangerous
because it is thinner and can be punctured easier. Top of tibia
below the knee. .....ANSWER..... What is the most common site for
bone marrow sampling in adults? What is the site used when this
cannot be reached? Site for infants and kids?
All bones in infants, only flat bones in adults. .....ANSWER.....
Where is bone marrow in infants and adults?
Main artery enters and branches to the periphery to form
vascular sinuses. Sinuses combine to form veins to reenter to
circulation. Just outside the sinuses are hematopoietic cords
containing cells. .....ANSWER..... What is the structure of the bone
marrow?
Through fenestrations in the lining cells of the sinus, which are
basically adjustable holes between epithelial cells.
.....ANSWER..... After maturation, how do cells enter the sinus?
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Macrophages bring iron to the RBCs. .....ANSWER..... RBCs are
inside a sinus, around a macrophage. Why?
Stromal cells. Reticulum that extends into the marrow cords, fat,
histiocytes, and endothelial cells. .....ANSWER..... What forms the
formation and support network inside the bone? What is it
comprised of?
Osteoblasts. Osteoclasts. Core biopsy. .....ANSWER..... Which
cells are bone forming? Bone destroying? Where can both of
these be seen?
Around a spicule .....ANSWER..... Where should a differential be
done on a bone marrow slide?
It supplies mature cells for circulation in a steady state or for
increased demand. Maintained by pluripotent stem cells. Cells
proliferate according to the stimulus they receive. .....ANSWER.....
What is the function of bone marrow? What is bone marrow self
renewal maintained by? How do cells what to proliferate into?
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RBCs - 120 days. WBCs - 5-20 days. .....ANSWER..... What is the
lifespan of RBCs and WBCs?
Only when it is necessary to diagnose them or treat them.
.....ANSWER..... When should you aspirate a patient?
Anemia, polycythemia, leukopenia, and thrombocytosis.
.....ANSWER..... Which diseases affect bone marrow composition?
Metastasizing tumors that have spread to the bone marrow such
as Hodgkin's lymphoma. Causes a spot of BM to not be able to
produce and will prevent a sample being taken from that area.
A fever of unknown origin will also affect BM production.
Hereditary diseases such as Gaucher (a storage pool disease)
will also affect. .....ANSWER..... What diseases would affect the
production of bone marrow?
Try to match the site by going to other side. Only aspirate
sternum if absolutely necessary. .....ANSWER..... If a tumor is