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UTMB N534 Advanced Pathophysiology Exam 1 Review: Cellular & Genetic Basis of Disease

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A comprehensive review for the UTMB Graduate School of Biomedical Sciences N534 (5355) Advanced Pathophysiology Exam 1. This guide covers foundational principles including cellular injury, adaptation, death (necrosis/apoptosis), inflammation, tissue repair, and genetic disorders. Essential for mastering the mechanisms of disease at the cellular and molecular level.

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Page 1 of 33


UTMB 5355 ADVANCED PATHOPHYSIOLOGY EXAM 2,

3 & 4 NEWEST 2025 PACKAGE DEAL| 3 LATEST

VERSIONS WITH COMPLETE REAL EXAM QUESTIONS

AND CORRECT DETAILED ANSWERS (VERIFIED

ANSWERS) ALREADY GRADED A+| BRAND NEW!!

Biogenic Amine Theory linked to depression .....ANSWER.....

Deficiency of neurotransmitters in brain of norepinephrine,

dopamine, and/or serotonin. Particularly, a decrease in receptor

binding with serotonin.

Neurotransmitter Receptor Hypothesis linked to depression

.....ANSWER..... A deficiency of monoamine neurotransmitters at

neuronal synapses.

Antidepressants increase .....ANSWER..... Neuronal synaptic levels

of monoamine neurotransmitters.

,Page 2 of 33


if you have more receptors than neurotransmitters .....ANSWER.....

Neurotransmitters do not have time to re-charge thus, they do not

function properly.

Hypothalamic-Pituitary-Adrenal (HPA) System Dysregulation

.....ANSWER..... HPA system dysregulation with excessive

glucocorticoid secretion is found in a large percentage of people

suffering from major depression.

Patho of Alzheimer's includes - plaque formation, presence of --,

with decreased levels of - .....ANSWER..... Amyloid B,

neurofibrillary tangles, acetylcholine these disrupt impulse

transmission

neurofibrillary tangles .....ANSWER..... are a deformation of the

structure that carries nutrients to neurons of the brain.

Decreased levels of choline acetyl transferase and acetylcholine

is associated with .....ANSWER..... Memory loss

,Page 3 of 33


Most common cause of dementia .....ANSWER..... Alzheimer's

disease fatal 5-10 years

Characteristics of Alzheimer's .....ANSWER..... Loss of memory,

language , inability to learn new things, dysfunction, delusions,

cannot perform ADLs, majorly effects social life

Parkinson's Disease is .....ANSWER..... Chronic motor progressive

neuro-degenerative known as a shaking palsy

Parkinson's disease is associated with .....ANSWER..... basal

ganglia dysfunction and atrophy of neurons in the substantia

nigra that produce dopamine;

Characteristics of Parkinson's disease .....ANSWER..... Tremors at

rest, rigidity, bradykinesia, muscular rigidity and postural

abnormalities.

2 Main Categories of CVA .....ANSWER..... Hemorrhagic and

Ischemic

, Page 4 of 33


Hemorrhagic CVA .....ANSWER..... Blood produces inflammatory

reaction, swelling, displaces brain tissue and increases ICP

2 types of hemorrhagic stroke .....ANSWER..... Intracerebral and

subarachnoid

Intracerebral Hemorrhage .....ANSWER..... Blood vessel leaks

directly into brain tissue

Subarachnoid hemorrhage .....ANSWER..... Bleeding into the

subarachnoid space, caused by trauma, aneurysm rupture

presents as "worst headache of life". surgical emergency

Ischemic CVA .....ANSWER..... reduction in cerebral blood flow

results in hypoxia and irreversible cell death with associated

cerebral edema

3 types of ischemic CVA .....ANSWER..... thrombotic, embolic,

hypercoagulable states.

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