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Chamberlain College of Nursing
Alterations in Neurological Functioning Study
Guide
Course: NR546/NR 546 Advanced
Pharmacology: Psychopharmacology
, Anxiolytic Medications Table
Week 4
THIS ASSIGNMENT SHOULD BE SUBMITTED TO THE WEEK 4
Drug Name/ Indication Associated Half-life (T1/2) Notable side effects
Medication class list diagnosis and Neurotransmitters Metabolism (CYP
targeted symptoms 450 enzyme)
Gabapentin -partial seizures with or -Glutamate Half life (T1/2): Notable side effects:
without secondary -approx. 5-7 hours -sedation (dose-dependent), dizziness
-glutamate, voltage- generalization - GABA -ataxia (dose-dependent), fatigue,
gated calcium Metabolism: nystagmus, tremor
channel blocker (Glu- -Postherpetic neuralgia -peripheral edema
CB) -not metabolized -blurred vision
-restless leg syndrome but excreted intact -vomiting, dyspepsia, diarrhea, dry
-anticonvulsant (extended-release) renally mouth, constipation, weight gain
-additional <12yr old: hostility,
-antineuralgic for -neuropathic pain/chronic emotional liability, hyperkinesia, thought
chronic pain pain, anxiety disorder, weight gain
(adjunctive), and bipolar
-alpha 2 delta ligands disorder (adjunctive)
at voltage-sensitive [not FDA approved]
calcium channels
Pregabalin -diabetic peripheral -Glutamine Half-life (T1/2): Notable side effects:
[Lyrica, Lyrica CR] neuropathy (IR and CR) -approx. 5-7 hours -sedation, dizziness
-norepinephrine -ataxia, fatigue, tremor, dysarthria,
-glutamate, voltage- -postherpetic neuralgia Metabolism: paresthesia, memory impairment,
gated calcium -serotonin coordination abnormal, impaired
channel blocker (Glu- -Fibromyalgia (IR) -not metabolized attention, confusion, euphoric mood,
CB) -dopamine but excreted intact irritability
-Neuropathic pain renally -vomiting, dry mouth, constipation,
-anticonvulsant associated with spinal -substance P weight gain, increased appetite,
cord injury (IR) flatulence
Chamberlain College of Nursing
Alterations in Neurological Functioning Study
Guide
Course: NR546/NR 546 Advanced
Pharmacology: Psychopharmacology
, Anxiolytic Medications Table
Week 4
THIS ASSIGNMENT SHOULD BE SUBMITTED TO THE WEEK 4
Drug Name/ Indication Associated Half-life (T1/2) Notable side effects
Medication class list diagnosis and Neurotransmitters Metabolism (CYP
targeted symptoms 450 enzyme)
Gabapentin -partial seizures with or -Glutamate Half life (T1/2): Notable side effects:
without secondary -approx. 5-7 hours -sedation (dose-dependent), dizziness
-glutamate, voltage- generalization - GABA -ataxia (dose-dependent), fatigue,
gated calcium Metabolism: nystagmus, tremor
channel blocker (Glu- -Postherpetic neuralgia -peripheral edema
CB) -not metabolized -blurred vision
-restless leg syndrome but excreted intact -vomiting, dyspepsia, diarrhea, dry
-anticonvulsant (extended-release) renally mouth, constipation, weight gain
-additional <12yr old: hostility,
-antineuralgic for -neuropathic pain/chronic emotional liability, hyperkinesia, thought
chronic pain pain, anxiety disorder, weight gain
(adjunctive), and bipolar
-alpha 2 delta ligands disorder (adjunctive)
at voltage-sensitive [not FDA approved]
calcium channels
Pregabalin -diabetic peripheral -Glutamine Half-life (T1/2): Notable side effects:
[Lyrica, Lyrica CR] neuropathy (IR and CR) -approx. 5-7 hours -sedation, dizziness
-norepinephrine -ataxia, fatigue, tremor, dysarthria,
-glutamate, voltage- -postherpetic neuralgia Metabolism: paresthesia, memory impairment,
gated calcium -serotonin coordination abnormal, impaired
channel blocker (Glu- -Fibromyalgia (IR) -not metabolized attention, confusion, euphoric mood,
CB) -dopamine but excreted intact irritability
-Neuropathic pain renally -vomiting, dry mouth, constipation,
-anticonvulsant associated with spinal -substance P weight gain, increased appetite,
cord injury (IR) flatulence
