APHON Principles of Chemo and Biotherapy
1.Biotherapy: Targeted anticancer agents also known as biological response modifiers (BRM)
2.Tyrosine kinase inhibitors (TKIs) are what class: Biotherapy
3.Monoclonal antibodies (MoAbs) are what class: Biotherapy
4.Define pharmacokinetics: Study of drug absorption, metabolism, and excretion
5.Define pharmacodynamics: The concentration of the drug in the body and how it produces a response
6. Define adjuvant chemotherapy: The use of chemo after another type of therapy, such as surgery, to treat residual disease or
undetectable metastasis.
7. Define neoadjuvant chemotherapy: When chemo is used preoperatively to decrease tumor burden in order to make it easier
to remove the tumor surgically.
8. Define sanctuary sites: Sites within the body where tumor cells sequester and are not easily reached by chemo such as the
CNS
9.What normal cells are most often effected by chemotherapy: Hematopoietic, mucosal
(mouth & GI), hair follicles
10. Why use chemotherapy: To prevent cancer cells from dividing, metastasizing, and ultimately causing the death of the
patient
11. Cure: To permanently eradicate the cancer
12. Control: To extend the length & QOL when cure is not feasible or realistic
13. Palliation: Minimize pain and suffering during end of life
14. Resting phase of cell cycle: Gap 0 - cells not dividing
15. Postmitotic phase: Gap 1 - enzymes needed for DNA synthesis are produced, protein and RNA synthesis takes place
(18 Hours)
16. Synthesis (S) Phase: Cellular DNA duplicated (20 hours)
17. Premitotic phase: Gap 2 - both protein and RNA synthesis occur, precursors of mitotic spindle are produced. Shortest
phase
18. Mitosis (M) Phase: Cell division occurs in 4-step phase (prophase, metaphase, anaphase, telophase) 1 Hour
19. 5 stages of reproduction of cells: Resting, Postmitotic, synthesis, premitotic, mitosis
20. Cell Cycle time: The amount of time it takes a cell to move from one mitotic episode to another.
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1.Biotherapy: Targeted anticancer agents also known as biological response modifiers (BRM)
2.Tyrosine kinase inhibitors (TKIs) are what class: Biotherapy
3.Monoclonal antibodies (MoAbs) are what class: Biotherapy
4.Define pharmacokinetics: Study of drug absorption, metabolism, and excretion
5.Define pharmacodynamics: The concentration of the drug in the body and how it produces a response
6. Define adjuvant chemotherapy: The use of chemo after another type of therapy, such as surgery, to treat residual disease or
undetectable metastasis.
7. Define neoadjuvant chemotherapy: When chemo is used preoperatively to decrease tumor burden in order to make it easier
to remove the tumor surgically.
8. Define sanctuary sites: Sites within the body where tumor cells sequester and are not easily reached by chemo such as the
CNS
9.What normal cells are most often effected by chemotherapy: Hematopoietic, mucosal
(mouth & GI), hair follicles
10. Why use chemotherapy: To prevent cancer cells from dividing, metastasizing, and ultimately causing the death of the
patient
11. Cure: To permanently eradicate the cancer
12. Control: To extend the length & QOL when cure is not feasible or realistic
13. Palliation: Minimize pain and suffering during end of life
14. Resting phase of cell cycle: Gap 0 - cells not dividing
15. Postmitotic phase: Gap 1 - enzymes needed for DNA synthesis are produced, protein and RNA synthesis takes place
(18 Hours)
16. Synthesis (S) Phase: Cellular DNA duplicated (20 hours)
17. Premitotic phase: Gap 2 - both protein and RNA synthesis occur, precursors of mitotic spindle are produced. Shortest
phase
18. Mitosis (M) Phase: Cell division occurs in 4-step phase (prophase, metaphase, anaphase, telophase) 1 Hour
19. 5 stages of reproduction of cells: Resting, Postmitotic, synthesis, premitotic, mitosis
20. Cell Cycle time: The amount of time it takes a cell to move from one mitotic episode to another.
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