BIOPHARMACEUTICS AND
PHARMACOKINETICS
1.Liberation: It is defined as the release of drug from its dosage form:
2.I and II: Clinically, GFR is measured using which of the following drugs?
I. Inulin
II. Creatinine
III.Creatine
IV. Insulin
3.Fraction of the administered drug that reaches the systemic circulation.: Which of the following statements best describes F?
4.Dose/AUC: If the dose (X0) and AUC are unknown, clearance (area method) is calculated by:
5.125 mg/500 mg = 0.25: If 500 mg of a drug is given orally and 125 mg is absorbed into the systemic circulation, what is F?
6.I only: For the body fluid compartments below, rank them from the lowest volume to the highest, in a typical 70-kg person:
I. Plasma < extracellular fluid < intracellular < total body water
II. Total body water < extracellular fluid < intracellular < Plasma
III.Plasma < Intracellular < Extracellular Fluid < Total body water
7.Drug is not well-distributed.: If the VD is approximately 5 liters?
8.I, II and III: The superfamily of enzyme responsible for oxidative metabolism of drugs during Phase I drug biotransformation:
I. Mixed Function Oxidases
II. Mono-oxygenase
III.CYP450
IV. Hydrogenase
9. renal and biliary: Two important routes of drug excretion are:
10. Fick's law: What governs the principle of diffusion?
11. Glucuronidation: Which of the following is not a Phase I reaction?
, 12. disease and genetics: Biotransformation may be dependent on factors such as age, ____, ______.
13. Metabolism: The conversion of drug to inactive, polar and non-toxic form is called:
14. Biotransformation: The body converts a drug to a less active substance by a process called:
15 Terminal Elimination Rate Constant: Which of the following is the best definition of beta (B)?
16. I, II and III: Which is the following plasma proteins and their function is correctly matched?
I. albumin - acidic drugs
II. alpha-acid glycoprotein - basic drugs
III.globulin - hormones
17. Bioavailability: The extent to which a drug is absorbed partially determines its:
18. Metabolism: Biotransformation is also known as:
19. First-pass: Which of the following types of metabolism do drugs with a high extraction ratio undergo to a significant
extent?
20. Hepatic Blood Flow: Because the extraction ratio can maximally be 1, the maximum value that hepatic clearance can
approach is that of:
21. Pharmacokinetics: The study of the time course of drug absorption, distribution, metabolism, and excretion is called:
22. I and III: Enzyme inhibitors:
I. Grapefruit juice
II. St. John's Wort
III.Macrolides
23. I and II: What are the 2 important physiologic factors affecting distribution?
I. Cardiac Output
II. Regional blood flow
III.Volume of Distribution
24. Excretion Rate: Renal clearance can be calculated from the ratio of which of the following rates to the drug's
concentration in plasma?
25. Membrane Thickness: Which of the following factors in which the rate of transport has inverse relationship with?
PHARMACOKINETICS
1.Liberation: It is defined as the release of drug from its dosage form:
2.I and II: Clinically, GFR is measured using which of the following drugs?
I. Inulin
II. Creatinine
III.Creatine
IV. Insulin
3.Fraction of the administered drug that reaches the systemic circulation.: Which of the following statements best describes F?
4.Dose/AUC: If the dose (X0) and AUC are unknown, clearance (area method) is calculated by:
5.125 mg/500 mg = 0.25: If 500 mg of a drug is given orally and 125 mg is absorbed into the systemic circulation, what is F?
6.I only: For the body fluid compartments below, rank them from the lowest volume to the highest, in a typical 70-kg person:
I. Plasma < extracellular fluid < intracellular < total body water
II. Total body water < extracellular fluid < intracellular < Plasma
III.Plasma < Intracellular < Extracellular Fluid < Total body water
7.Drug is not well-distributed.: If the VD is approximately 5 liters?
8.I, II and III: The superfamily of enzyme responsible for oxidative metabolism of drugs during Phase I drug biotransformation:
I. Mixed Function Oxidases
II. Mono-oxygenase
III.CYP450
IV. Hydrogenase
9. renal and biliary: Two important routes of drug excretion are:
10. Fick's law: What governs the principle of diffusion?
11. Glucuronidation: Which of the following is not a Phase I reaction?
, 12. disease and genetics: Biotransformation may be dependent on factors such as age, ____, ______.
13. Metabolism: The conversion of drug to inactive, polar and non-toxic form is called:
14. Biotransformation: The body converts a drug to a less active substance by a process called:
15 Terminal Elimination Rate Constant: Which of the following is the best definition of beta (B)?
16. I, II and III: Which is the following plasma proteins and their function is correctly matched?
I. albumin - acidic drugs
II. alpha-acid glycoprotein - basic drugs
III.globulin - hormones
17. Bioavailability: The extent to which a drug is absorbed partially determines its:
18. Metabolism: Biotransformation is also known as:
19. First-pass: Which of the following types of metabolism do drugs with a high extraction ratio undergo to a significant
extent?
20. Hepatic Blood Flow: Because the extraction ratio can maximally be 1, the maximum value that hepatic clearance can
approach is that of:
21. Pharmacokinetics: The study of the time course of drug absorption, distribution, metabolism, and excretion is called:
22. I and III: Enzyme inhibitors:
I. Grapefruit juice
II. St. John's Wort
III.Macrolides
23. I and II: What are the 2 important physiologic factors affecting distribution?
I. Cardiac Output
II. Regional blood flow
III.Volume of Distribution
24. Excretion Rate: Renal clearance can be calculated from the ratio of which of the following rates to the drug's
concentration in plasma?
25. Membrane Thickness: Which of the following factors in which the rate of transport has inverse relationship with?
