Imperial College London (ICL)

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, cardiovascular and thoracic biology (CTB) module. Lecture 7 on cell biology of the cardiovascular system: how cellular components of the cardiovascular system help maintain vascular homeostasis. Homeostasis is a healthy state that is maintained by the constant adjustment of biochemical and physiological pathways. An example of homeostasis is the maintenance of a constant blood pressure in the human body. lear...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, cardiovascular and thoracic biology (CTB) module. lecture 6 on cell biology of the respiratory tract (airways and lungs): how the tract protects itself from inhaled insult, and is able to control the calibre of the airways to limit penetration by larger objects. learning objectives: LO1: Describe the structure and function of the main cell types in the respiratory tract (aka airways and lungs). LO2: Describe...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, cardiovascular and thoracic biology (CTB) module. Lecture 4 on the regulation of blood pressure and flow: - Explain the basic physical principles governing flow and pressure in the circulation. - Describe how vascular resistance is regulated. - Explain how exercise affects the circulation. - Summarise how vascular compliance helps maintain steady blood flow. - Define the terms systolic pressure, diastolic p...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, cardiovascular and thoracic biology (CTB) module. Lecture 2 on the mechanical and electrical properties of the heart and cardiomyocyte biology. learning objectives: LO1: Evaluate the impact of cardiomyocyte structure on its function LO2: Explain mechanical properties of the heart LO3: Explain electrical properties of the heart

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, cardiovascular and thoracic biology (CTB) module. CTB 8 on anaphylaxis: a not uncommon allergic, potentially life-threatening condition that involves both the respiratory and cardiovascular systems. learning objectives: LO1: List the cardinal signs of acute inflammation and anaphylaxis and describe the physiological mechanisms that bring these about. LO2: Summarise the progress of an immune response to an an...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, cardiovascular and thoracic biology (CTB) module. In this chapter, we are going to take a step into the future to see where current thinking about respiratory and cardiovascular diseases is heading, in particular thinking about where we may be in 10- 15 years’ time. It is a very exciting time for medical research in general, and including respiratory and cardiovascular research, with numerous new technologies ...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 9 on obesity: In this session, we will turn our attention to a different challenge: pharmaceuticals for treating obesity. We will start by defining what we mean by the term obese, before considering the fundamental causes, and pharmacologically-relevant mechanisms that contribute to obesity. Later, we will explore pharmaceuticals that are in use (or have previously been used) to treat o...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 9 on obesity: In this session, we will turn our attention to a different challenge: pharmaceuticals for treating obesity. We will start by defining what we mean by the term obese, before considering the fundamental causes, and pharmacologically-relevant mechanisms that contribute to obesity. Later, we will explore pharmaceuticals that are in use (or have previously been used) to treat o...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 9 on obesity: In this session, we will turn our attention to a different challenge: pharmaceuticals for treating obesity. We will start by defining what we mean by the term obese, before considering the fundamental causes, and pharmacologically-relevant mechanisms that contribute to obesity. Later, we will explore pharmaceuticals that are in use (or have previously been used) to treat o...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, pharmacology module. Phar 1 module on introduction to pharmacology with pharmacodynamics: learning outcomes: - LO1 Pharmacodynamics: Define what is meant by a ‘drug’ and a ‘drug target site’. - LO2 Target sites: List the four main categories of drug target sites. - LO3 Selectivity: Explain the concept of drug selectivity (cf. specificity) and how this relates to ‘structure activity relationsh...