University of Southampton (UOS)

Lecture notes from BIOL3015 Regulation of gene expression, transcriptional regulation. Covering: regulatory circuits, negative feedback, toggle switch circuits, somitogenesis oscillator, circadian clocks, transcriptional circuits of fruit flies, transcriptional circuits of mammalian clocks, transcriptional circuits of budding yeast cell cycle, northern blot, qRT-PCR, 'Sanger' sequencing, 'Next generation' sequencing and transcriptional phenotyping.

Lecture notes from a series of lectures in BIOL3015 Regulation of Gene Expression, epigenetics. Covering: DNA methylation, chromatin structure, epigenetic modifiers, non-coding RNAs, Epigenetics and disease, social environment, cancer and tumour supression

Lecture notes from BIOL3015 regulation of gene expression, transcriptional control and genetic diseases. Covering: transcriptional control, TATA box, TATA-less promotors, MyoD gene, activation domains, transcriptional factors

Questions and answers based on BIOL2045 Vertebrate Development lectures. Covering topics: Stem cells, Vertebrate Gastrulation, Neural tube formation and neural crest development, Gametogenesis/Sex determination, fertilisation, cleavage to implantation and implantation

Lecture Notes from the BIOL2045 Vertebrate Development stem cells. Covering: what are stem cells, potency, regulation, embryonic stem cells, ICM cells, cerebral organoids, hES cells

Lecture notes from BIOL2018 Adaptive physiology Immunology. Covering: Innate vs acquired immunology, Anti-microbial peptides, phagocytosis, Dscam protein, cellular and humoral responses in fish and Mammalian type adaptive immune system

Lecture notes from Biol2018 adaptive physiology Diving and High altitude physiology. Covering: adverse effcts of diving, the bends, oxygen toxicity, metabolic rates, effects of high pressure, increasing oxygen availability - high altitude, altitude sickness, haemoglobin and oxygen affinity

Lecture notes from various lectures in BIOL2018 adaptive physiology, temperature regulation. Covering: environmental and body temperature relationships, strategies in thermal regulation, temperatures' dominant effect on biological processes, ectotherms, thermoreception and dormancy

C. elegans is often a subject choice for lab testing due to there internal systems similar to that of humans. These lecture notes cover multiple lectures discussing C. elegans. Covering: an introduction to C. elegans, C. elegans adaptations to feeding, egg laying, environmental cues and development.

Lecture notes from BIOL2018 adaptive physiology, osmoregulation. Covering: maintenance of homeostatic internal environment, water and ion exchange, osmo-conformers vs -regulators, excretory products, urine, kidneys, cartilaginous fish, marine fish, freshwater fish, freshwater to seawater exchanges and vice versa, osmoregulation on land, salt glands, nitrogen excretion, ammonia and uric acid.