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Antiphospholipid antibodies and cerebrovascular thrombosis in the pediatric population: Few answers to many questions
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---25August 20242024/2025A+
- 2. Antiphospholipid antibodies and cerebral thrombosis 
2.1. Lupus anticoagulant 
In neonates and children, LAC are sometimes found incidentally due to prolongation of activated 
partial thromboplastin time (20). As LAC can be transient and associated with infections and 
transplacental passage (21, 22), they are not usually associated with clinically relevant complications 
(23). Therefore, the differentiation between de novo and acquired LAC has important therapeutic 
implications and is c...
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