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WEEK 1 CELLULAR BIOLOGY AND ALTERATIONS.
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32

May 2025

2024/2025

A+
• Retinoblastoma is a rare cancer that occurs only in children. It develops either as a hereditary disease, due to an abnormality of the RB1 gene, or sporadically (70% of cases). Located on chromosome 13q14, the RB1 gene is responsible for encoding pRb, which is a tumor suppressor protein. In the heritable form, the RB1 gene mutation is inherited through germinal cells, with a second mutation occurring in somatic retinal cells. The noninherited type of retinoblastoma occurs as a result of two...
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