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ESMO - Magnitude of Clinical Benefit Scale V.1.0 questions and answers
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---7augustus 20242024/2025A+
- If the ESMO-MCBS is only to be applied to comparative 
studies, what will that mean for breakthrough therapies, 
licenced on single arm data? 
Answer 
▸ The grading of single arm data will be incorporated 
into version 1.1 of the ESMO-MCBS. 
Evaluation form 1—for new approaches to adjuvant 
therapy or new potentially curative therapies grade A (for 
grade B and C analogously): What is the specific meaning 
of ‘in studies without mature survival data’? Assuming we 
have survival data at 3...
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