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Fundamentals of Chemotherapy 2023 with 100% correct questions and answers
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4

February 2023

2022/2023

A+
Alkylating Agents MOA -Inactive until metabolized by the microsomal P450 system -Metabolism forms highly reactive electrophils that react with neutrophiic groups cross-linking DNA and interfering with its function Classical = carmustine, cyclophosphamide, mechlorethamine Non-Classical = procarbazine, dacarbazine, temazolamide, bendamustine Cyclophosphamide -Classical alkylating agent Toxicity - bone marrow suppression (days 8-14), cystitis, cardiac toxicity (high doses), immunosupp...
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