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Exam (elaborations)
Intermediate filaments: new proteins, some answers, more questions
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---9August 20242024/2025A+
- At this point, I would like briefly to draw attention to 
an intriguing and rather heterodox proposal, made by 
Lai et al. [61"]. Vimentin is a major cellular phosphoprotein and its level of phosphorylation changes during 
the cell cycle. Aside from a likely role in the disruption of 
vimentin filaments in the region of the contractile ring 
during cytokinesis (see [62,63]), the physiological significance ofvimentin phosphorylation remains unclear. On 
the basis of a study of four diffe...
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Exam (elaborations)
Intermediate filaments: new proteins, some answers, more questions
-
---9August 20242024/2025A+
- A second group, the neuronal clFps, are related more 
in terms of intron/exon structure than primary se- 
quence. This group contains the rather divergent clF 
proteins NF1, NFm, NFh, 0t-internexin and nestin. It 
appears that these proteins can all co-polymerize with 
vimentin and, from the point of view of IF network 
formation, may be viewed as partners of vimentin. 
There is, however, a clear-cut distinction between the 
[-352 amino acid central s-helical domain 
Nuclear lamins -I N...
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