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Methotrexate in juvenile idiopathic arthritis: advice and recommendations from the MARAJIA expert consensus meeting
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---14augustus 20242024/2025A+
- Only Foell et al. in a randomized clinical trial proved the 
 safety of withdrawing MTX therapy after 6 months of 
 stable remission versus 12 months. The results of this 
 study that included 364 patients showed that a 12-month 
 versus 6-month withdrawal of MTX did not reduce the re 
lapserate[51]. 
 MTX withdrawal may result in disease flare in more 
 than 50% of patients, and even more in younger children. 
 A longer period on MTX treatment after remission may 
 not prolong the duration of i...
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