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Role of RGC-32 in multiple sclerosis and neuroinflammation – few answers and many questions
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9

August 2024

2024/2025

A+
RGC-32 as a key regulator of Th17 cell differentiation Using an RGC-32 knock-out (KO) mouse model, we have been able to demonstrate that RGC-32 promotes the differentiation of Th17 cells both in vitro and in vivo. When compared to wild-type (WT) cells, CD4+ cells isolated from RGC-32 KO mice express lower levels of IL-17, as well as some of the transcription factors necessary for Th17 differentiation, including retinoic acid receptor-related orphan receptor gamma t (RORgt), B cell–ac...
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