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Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?
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6

augustus 2024

2024/2025

A+
Relationship between CPVT/ARVD2 mutational locus in RyR2 and the type of amino acid change Left-hand panel: schematic diagram to illustrate CPVT/ARVD2 mutations clustered in discrete regions of the RyR2 polypeptide; the N-terminus (residues 77–1724, mutations denoted by yellow triangles), the central domain (residues 2246–2534, blue triangles), the cytoplasmic portion of the I-domain (residues 3778–4201, green stars) and the transmembrane domains (residues 4497–4959, red circles). Mu...
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