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FUNDAMENTALS OF CLINICAL TRIALS
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---560September 20222022/2023A+
- Chapter 1 
Introduction to Clinical Trials 
The evolution of the modern clinical trial dates back at least to the eighteenth 
century [1, 2]. Lind, in his classical study on board the Salisbury, evaluated six 
treatments for scurvy in 12 patients. One of the two who was given oranges and 
lemons recovered quickly and was fit for duty after 6 days. The second was the best 
recovered of the others and was assigned the role of nurse to the remaining ten 
patients. Several other comparative studies ...
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