lOMoAR cPSD| 57629747
WGU D116 ADVANCED PHARMACOLOGY
TEST BANK 2026: 300+ QUESTIONS AND
100% VERIFIED ANSWERS ( ANSWER
KEYS AVAILABLE AT THE END ) GRADED
A+ | GUARANTEED PASS!!
, lOMoAR cPSD| 57629747
D116 Practice Questions
1. A patient receives a drug that has a narrow therapeutic range. What is the nurse
administering this medication expected to do?
a. Monitor plasma drug levels.
b. Teach the patient that maximum drug effects will occur within a short
period.
c. Administer this medication intravenously.
d. Administer the drug at intervals longer than the drug half-life.
2. A patient is receiving intravenous gentamicin. A serum drug test reveals toxic
levels. The dosing is correct, and this medication has been tolerated by this patient
in the past. What is a probable cause of the test result?
a. The patient is taking another medication that binds to serum albumin.
b. The drug was not completely dissolved in the IV solution.
c. The medication is being given at a frequency that is longer than its halflife.
d. A loading dose was not given.
3. ADME is often used to describe the components of pharmacokinetics. What does
ADME stand for?
a. Alimentary canal, digestive tract, metabolism, and excretion.
b. Action of digestion and medication elimination.
c. Action of drug and elimination of medication.
d. Absorption, distribution, metabolism, and elimination.
4. The volume of distribution increases as the concentration of a drug in the blood
plasma increases.
a. True
b. False
5. A patient reports becoming "immune" to a medication because it no longer works
to alleviate symptoms. The provider recognizes that this decreased effectiveness
is likely caused by __________.
a. Antagonists produced by the body that compete with the drug for receptor
sites.
b. Desensitization of receptor sites by continual exposure to the drug.
c. Decreased selectivity of receptor sites, resulting in a variety of effects.
d. Synthesis of more receptor sites in response to the medication.
6. What occurs when a drug binds to a receptor in the body?
a. It alters the receptor to become nonresponsive to its usual endogenous
molecules.
b. It prevents the action of the receptor by altering its response to chemical
mediators.
c. It increases or decreases the activity of that receptor.
d. It gives the receptor a new function.
7. Which pharmacodynamic principle is most correlated with drug toxicity?
a. Efficacy
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b. Therapeutic index
c. Competitive antagonists
d. Intrinsic activity
8. A patient who is taking morphine for pain asks the nurse how a pain medication
can also cause constipation. What is the nurse's response?
a. It can cause constipation in toxic doses.
b. It is selective to receptors that regulate more than one body process.
c. It binds to different types of receptors in the body.
d. It causes only one type of response, and the constipation is coincidental.
9. Which statement about food and drug interactions is true?
a. Medications are best absorbed on an empty stomach.
b. Some foods can inhibit CYP isoenzymes and alter drug metabolism.
c. Foods alter drug absorption and metabolism but not drug action.
d. Patient discomfort is the food and drug interaction of most concern.
10.With respect to the cytochrome P450 (CYP) system, what will result in a higher
concentration of a drug?
a. Induction of the enzyme.
b. Inhibition of the substrate.
c. Inhibition of the enzyme.
d. Induction of the substrate.
11.An advanced practice registered nurse (APRN) works in a urology clinic under the
supervision of a physician who does not restrict the types of medications the APRN
is allowed to prescribe. State law does not require the APRN to practice under
physician supervision. How would the APRN's prescriptive authority be described?
a. Independent
b. With limitation
c. Limited authority
12.Which drug requires registration with the Drug Enforcement Administration (DEA)
to prescribe?
a. Chlorpromazine
b. Chlorthalidone
c. Chlordiazepoxide
d. Chlorzoxazone
13.True or False: Your DEA registration allows you to prescribe Schedule II and
Schedule III controlled substances for addiction.
a. True
b. False
14.A patient with diabetes reports losing their job and an inability to purchase the
required medications. As the FNP, which action is most appropriate?
a. Provide a seven-day sample pack.
b. Prescribe a different medication.
c. Contact a different pharmacy.
d. Decrease the daily dose by half.
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15.A nurse is preparing to administer a drug. After reading the medication guide, the
nurse notes that the drug has been linked to symptoms of Parkinson disease in
some patients. What should the nurse do?
a. Ask the patient to report these symptoms, which are known to be
teratogenic effects.
b. Warn the patient about these effects and provide reassurance that this is
expected.
c. Observe the patient closely for such symptoms and prepare to treat them
if needed.
d. Request an order to evaluate the patient’s genetic predisposition to this
effect.
16.Macrolide antibiotics are classic inducers of common cytochrome enzymes.
a. True
b. False
17.The World Health Organization (WHO) accounts for the cost to the patient when
they consider rational drug use.
a. True
b. False
18.A patient diagnosed with bipolar disorder is prescribed daily lithium. Which action is
most important to determine whether the therapeutic level is maintained?
a. Administer medication at regular intervals.
b. Ensure periodic laboratory testing is completed.
c. Obtain preadministration blood work.
d. Assess the patient for adverse effects.
19.The drug manual states that older adult patients are at increased risk for hepatic
side effects. Which action is most important when prescribing this medication to an
80-year-old patient?
a. Give the medication intravenously so that the drug does not pass through
the liver.
b. Discontinue the order; the drug is contraindicated for this patient.
c. Ensure that the drug is given in the correct dose at the correct time to
minimize the risk of adverse effects.
d. Obtain pretreatment laboratory work.
20.Therapeutic drug monitoring promotes standardized dosing.
a. True
b. False
21.Which patient would benefit from invasive therapeutic drug monitoring?
a. The heart failure patient on digoxin.
b. The patient who has not seen results from two weeks of initial therapy of
citalopram.
c. The 55-year-old male who is unable to achieve and maintain an erection
with 25mg of sildenafil.
d. The toddler on oral amoxicillin for otitis media.
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WGU D116 ADVANCED PHARMACOLOGY
TEST BANK 2026: 300+ QUESTIONS AND
100% VERIFIED ANSWERS ( ANSWER
KEYS AVAILABLE AT THE END ) GRADED
A+ | GUARANTEED PASS!!
, lOMoAR cPSD| 57629747
D116 Practice Questions
1. A patient receives a drug that has a narrow therapeutic range. What is the nurse
administering this medication expected to do?
a. Monitor plasma drug levels.
b. Teach the patient that maximum drug effects will occur within a short
period.
c. Administer this medication intravenously.
d. Administer the drug at intervals longer than the drug half-life.
2. A patient is receiving intravenous gentamicin. A serum drug test reveals toxic
levels. The dosing is correct, and this medication has been tolerated by this patient
in the past. What is a probable cause of the test result?
a. The patient is taking another medication that binds to serum albumin.
b. The drug was not completely dissolved in the IV solution.
c. The medication is being given at a frequency that is longer than its halflife.
d. A loading dose was not given.
3. ADME is often used to describe the components of pharmacokinetics. What does
ADME stand for?
a. Alimentary canal, digestive tract, metabolism, and excretion.
b. Action of digestion and medication elimination.
c. Action of drug and elimination of medication.
d. Absorption, distribution, metabolism, and elimination.
4. The volume of distribution increases as the concentration of a drug in the blood
plasma increases.
a. True
b. False
5. A patient reports becoming "immune" to a medication because it no longer works
to alleviate symptoms. The provider recognizes that this decreased effectiveness
is likely caused by __________.
a. Antagonists produced by the body that compete with the drug for receptor
sites.
b. Desensitization of receptor sites by continual exposure to the drug.
c. Decreased selectivity of receptor sites, resulting in a variety of effects.
d. Synthesis of more receptor sites in response to the medication.
6. What occurs when a drug binds to a receptor in the body?
a. It alters the receptor to become nonresponsive to its usual endogenous
molecules.
b. It prevents the action of the receptor by altering its response to chemical
mediators.
c. It increases or decreases the activity of that receptor.
d. It gives the receptor a new function.
7. Which pharmacodynamic principle is most correlated with drug toxicity?
a. Efficacy
messages.downloaded_by
, lOMoAR cPSD| 57629747
b. Therapeutic index
c. Competitive antagonists
d. Intrinsic activity
8. A patient who is taking morphine for pain asks the nurse how a pain medication
can also cause constipation. What is the nurse's response?
a. It can cause constipation in toxic doses.
b. It is selective to receptors that regulate more than one body process.
c. It binds to different types of receptors in the body.
d. It causes only one type of response, and the constipation is coincidental.
9. Which statement about food and drug interactions is true?
a. Medications are best absorbed on an empty stomach.
b. Some foods can inhibit CYP isoenzymes and alter drug metabolism.
c. Foods alter drug absorption and metabolism but not drug action.
d. Patient discomfort is the food and drug interaction of most concern.
10.With respect to the cytochrome P450 (CYP) system, what will result in a higher
concentration of a drug?
a. Induction of the enzyme.
b. Inhibition of the substrate.
c. Inhibition of the enzyme.
d. Induction of the substrate.
11.An advanced practice registered nurse (APRN) works in a urology clinic under the
supervision of a physician who does not restrict the types of medications the APRN
is allowed to prescribe. State law does not require the APRN to practice under
physician supervision. How would the APRN's prescriptive authority be described?
a. Independent
b. With limitation
c. Limited authority
12.Which drug requires registration with the Drug Enforcement Administration (DEA)
to prescribe?
a. Chlorpromazine
b. Chlorthalidone
c. Chlordiazepoxide
d. Chlorzoxazone
13.True or False: Your DEA registration allows you to prescribe Schedule II and
Schedule III controlled substances for addiction.
a. True
b. False
14.A patient with diabetes reports losing their job and an inability to purchase the
required medications. As the FNP, which action is most appropriate?
a. Provide a seven-day sample pack.
b. Prescribe a different medication.
c. Contact a different pharmacy.
d. Decrease the daily dose by half.
messages.downloaded_by
, lOMoAR cPSD| 57629747
15.A nurse is preparing to administer a drug. After reading the medication guide, the
nurse notes that the drug has been linked to symptoms of Parkinson disease in
some patients. What should the nurse do?
a. Ask the patient to report these symptoms, which are known to be
teratogenic effects.
b. Warn the patient about these effects and provide reassurance that this is
expected.
c. Observe the patient closely for such symptoms and prepare to treat them
if needed.
d. Request an order to evaluate the patient’s genetic predisposition to this
effect.
16.Macrolide antibiotics are classic inducers of common cytochrome enzymes.
a. True
b. False
17.The World Health Organization (WHO) accounts for the cost to the patient when
they consider rational drug use.
a. True
b. False
18.A patient diagnosed with bipolar disorder is prescribed daily lithium. Which action is
most important to determine whether the therapeutic level is maintained?
a. Administer medication at regular intervals.
b. Ensure periodic laboratory testing is completed.
c. Obtain preadministration blood work.
d. Assess the patient for adverse effects.
19.The drug manual states that older adult patients are at increased risk for hepatic
side effects. Which action is most important when prescribing this medication to an
80-year-old patient?
a. Give the medication intravenously so that the drug does not pass through
the liver.
b. Discontinue the order; the drug is contraindicated for this patient.
c. Ensure that the drug is given in the correct dose at the correct time to
minimize the risk of adverse effects.
d. Obtain pretreatment laboratory work.
20.Therapeutic drug monitoring promotes standardized dosing.
a. True
b. False
21.Which patient would benefit from invasive therapeutic drug monitoring?
a. The heart failure patient on digoxin.
b. The patient who has not seen results from two weeks of initial therapy of
citalopram.
c. The 55-year-old male who is unable to achieve and maintain an erection
with 25mg of sildenafil.
d. The toddler on oral amoxicillin for otitis media.
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