LE 4 – Volume Regulation
November 22 n d , 2023
Volume regulation
Regulati on of salt
Molecule Sodium
Concept Water follows sodium
Hormone Renin, Angiotensin, Aldosterone (RAAS)
Disease Hypo/hypervolemia, hypo/hypertension
Potassium salts better than sodium salt. less change of hypertension and cardiovascular disease.
Why does salt determine blood pressure?
Blood pressure = cardiac output x
peripheral resistance.
Cardiac output is determined by heart
rate and circulating volume. Circulating
volume is determined by Na+ uptake,
because waters passively follows Na +.
defects in Na+ regulation therefore
result in a disturbed blood pressure.
, Na+ reabsorbed along the tubule
Regulation of Na+ reabsorption
November 22 n d , 2023
Volume regulation
Regulati on of salt
Molecule Sodium
Concept Water follows sodium
Hormone Renin, Angiotensin, Aldosterone (RAAS)
Disease Hypo/hypervolemia, hypo/hypertension
Potassium salts better than sodium salt. less change of hypertension and cardiovascular disease.
Why does salt determine blood pressure?
Blood pressure = cardiac output x
peripheral resistance.
Cardiac output is determined by heart
rate and circulating volume. Circulating
volume is determined by Na+ uptake,
because waters passively follows Na +.
defects in Na+ regulation therefore
result in a disturbed blood pressure.
, Na+ reabsorbed along the tubule
Regulation of Na+ reabsorption
