Oefenvragen Celbiologie en kanker

Questions Cell Biology and Cancer
Which of the following is a major consequence of activation of phospholipase C-β
(PLCPLCβ) by the Gq trimeric GTPase?
- Elevation of intracellular Ca2+ levels, leading to the activation of protein kinase C
- Elevation of intracellular cAMP levels, leading to the activation of protein kinase A
- Elevation of PIP3 levels in the plasma membrane, leading to the activation of protein
kinase B.
- Elevation of IP3 in the plasma membrane, leading to the activation of protein kinase D
- Elevation of intracellular cGMP levels, leading to the activation of protein kinase G

Which of the following is NOT a common second or third messenger in cell signaling?
- Diacylglycerol
- Ca2+
- Cyclic adenosine monophosphate cAMP
- Tyrosine
- Inositol triphosphate

Carcinoma cells that have acquired malignancy and started local invasiveness to
begin metastasis …
- Decrease the expression of E-cadherin and undergo epithelial–mesenchymal
transition.(PLCEMT)
- MET

Sort the following events to reflect the normal order in which they occur in G-protein-
coupled receptor signaling leading to transcription of genes with cAMP response
elements.
1. Activation of adenylyl cyclase
2. Binding of cAMP to PKA
3. Dissociation of PKA into catalytic and regulatory subunits
4. Binding of CREB to PKA

What is the major way by which the monomeric G protein Ras is activated in receptor
tyrosine kinase signaling?
- Activation of Ras-GEF
- Activation of Ras-GAP
- Inactivation of Ras-GAP
- Inactivation of Ras GEF
- Inactivation of Ras-GD

What is counteracted by PTEN phosphatase?
- PI 3-kinase