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PCOL 824 Final Exam ACTUAL Exam Questions and CORRECT Answers
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---8oktober 20242024/2025A+
- PCOL 824 Final Exam ACTUAL Exam 
Questions and CORRECT Answers 
serotonin receptor (5HT2C) - CORRECT ANSWER- serotonin binding activates the 
satiety pathway 
leptin - CORRECT ANSWER- -hormone produced in fat cells 
-stimulates the satiety pathway and inhibits the hunger pathway 
ghrelin - CORRECT ANSWER- stimulates the NPY pathway (hunger
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PCOL 824 Final Exam UPDATED ACTUAL Exam Questions and CORRECT Answers
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---12oktober 20242024/2025A+
- PCOL 824 Final Exam UPDATED 
ACTUAL Exam Questions and CORRECT 
Answers 
Acetylcholine - CORRECT ANSWER- Endogenous ligand for nicotinic and muscarinic 
receptors. Easily hydrolyzed by acetylcholinesterase. 
Methacholine - CORRECT ANSWER- Methylated version of ACh makes it less 
susceptible to hydrolysis. Has high affinity for muscarinic receptors and no affinity for 
nicotinic receptors
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PCOL 824 Exam 3 Questions with Correct Answers
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---5maart 20242023/2024A+
- PCOL 824 Exam 3 Questions with Correct Answers 
 
cholinergic receptor sites are either.... - Answer-muscarinic or nicotinic 
 
cardiac muscle - Answer-M-2 
(cholinergic) 
 
exocrine glands - Answer-M-3 
(cholinergic) 
 
smooth muscle - Answer-M-3 
(cholinergic) 
 
ganglia (PNS & SNS) & adrenal medulla - Answer-N-neuronal 
(cholinergic) 
 
skeletal muscle end plate - Answer-N-muscle 
(cholinergic) 
 
sweat glands (sympathetic NS) - Answer-M-3 
(cholinergic) 
 
brain & spinal cord - Answer-M-1, N...
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PCOL 824 Final Exam Questions and Answers All Correct
-
---29maart 20242023/2024A+
- PCOL 824 Final Exam Questions and Answers All Correct 
list the choline esters (muscarinic agonists) - Answer-- acetylcholine 
 
- methacholine 
 
- carbachol 
 
- bethanechol 
 
what are the indications for muscarinic agonists? - Answer-- post operative urinary retention 
 
- decrease intraocular pressure 
 
- cause miosis during cataract removal 
 
- xerostomia in cancer patients 
 
what is cevimeline? - Answer-- muscarinic agonist 
 
- activates M3 for dry mouth 
 
list the reversible antich...
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PCOL 824 Exam 2 Questions with Correct Answers
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---3maart 20242023/2024A+
- PCOL 824 Exam 2 Questions with Correct Answers 
What is the equation for Vd? - Answer-Vd = initial dose of drug in body / concentration of drug in plasma 
 
High Vd - Answer-Drug is mostly found in tissues - not affected by changes to protein binding - favored being present in the cells 
 
Low Vd - Answer-Drug is mostly in blood - very protein bound (albumin) - sensitive to changes in protein binding 
 
Order of Lowest to Highest Vd - Answer-Drug that highly binds to proteins and cannot enter t...
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PCOL 824 Final Exam Questions with Answers All Correct
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---5maart 20242023/2024A+
- PCOL 824 Final Exam Questions with Answers All Correct 
serotonin receptor (5HT2C) - Answer-serotonin binding activates the satiety pathway 
 
leptin - Answer--hormone produced in fat cells 
-stimulates the satiety pathway and inhibits the hunger pathway 
 
ghrelin - Answer-stimulates the NPY pathway (hunger) 
 
amphetamine-like drugs - Answer--short term management of obesity (appetite suppressant) 
ADR: weight rebound 
 
orlistat - Answer-irreversible inhibitor of GI lipase (decreases fat a...
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PCOL 824 Test 2 Questions with Correct Answers
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---5maart 20242023/2024A+
- PCOL 824 Test 2 Questions with Correct Answers 
 
Types of bonds often seen in Drug-ReceptorInteractions - Answer-Electrostatic Interactions: (strongest first) 
1) Salt Bridges (ion-ion) (full charge on full charge Na+Cl-, much stronger) 
2) Pi-Cation (ion-dipole) the ion-dipole interaction (i.e. a fully charged species interacting with the opposite charge of a dipole) 
3) Neutral H-Bonds (dipole-dipole) 
 
4) Van der waals (C to C) 
*Aliphatic chains to Aliphatic chains 
Aliphatic chains to ar...
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PCOL 824 Final Exam Questions with Correct Answers
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---23maart 20242023/2024A+
- PCOL 824 Final Exam Questions with Correct Answers 
Which DM is insulin-dependent? - Answer-Type I DM 
 
Which DM is non-insulin-dependent? - Answer-Type II DM 
 
Which DM has a juvenile onset? - Answer-Type I DM 
 
Which DM is caused by a virus or environmental factors in genetically predisposed individuals? - Answer-Type I DM 
 
Which diabetes are beta cell insulin decreased or absent? - Answer-Type I DM 
 
In DM (type II and type I), lesions of blood vessels occur in the - Answer--Eye (retin...
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PCOL 824 Final Exam with Complete Solutions
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---9maart 20242023/2024A+
- PCOL 824 Final Exam with Complete Solutions 
Acetylcholine - Answer-Endogenous ligand for nicotinic and muscarinic receptors. Easily hydrolyzed by acetylcholinesterase. 
 
Methacholine - Answer-Methylated version of ACh makes it less susceptible to hydrolysis. Has high affinity for muscarinic receptors and no affinity for nicotinic receptors. 
 
Carbachol - Answer-Transaminated version of ACh that results in negligible hydrolysis for longer half life. Has normal affinity for nicotinic receptors...
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