GMS 6504

GMS6551 REVIEW FINAL EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED Which definition best describes a lead compound? - the compound that is used for in vivo experiments - the compound that is used for clinical trials - the first compound discovered to have the desired activity - the compound that is FDA approved The first compound discovered to have the desired activity Which method of discovering a drug is least expensive? - natural products - high-throughput screening - ...

GMS6402 PULMONARY FINAL EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED What is Atmospheric O2? 160 mmHg What is Inspired O2? 150 mmHg What is Alveolar O2? 100 mmHg What is Arterial O2 (PaO2)? 100 mmHg What is Arterial CO2 (PaCO2)? 40 mmHg What is the formula for compliance? C = deltaV / deltaP change in lung volume/ change in pressure The vast majority of the total surface area of the lung is found in the alveoli All of the following can be measured via spirometry EX...

GMS6504 LECTURE 2 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED What is Lipinski's Rule of 5 regarding molecular mass? Poor absorption or permeation are more likely when molecular mass is greater than 500 Da. What does Lipinski's Rule of 5 say about lipophilicity? Poor absorption or permeation are more likely when LogP is greater than 5. According to Lipinski's Rule of 5, how many hydrogen bond donors can a compound have? More than 5 hydrogen bond donors (OH, FH, N...

GMS6504 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED which of the following would best be described as a system independent parameter determining pharmacological response? •the number of receptors present •the cellular cascade •pharmacokinetics •receptor affinity for the ligand •presence of an antagonist receptor affinity for the ligand when taking a natural agonist and converting it to an antagonist using synthetic chemistry, what are the desired effects on...

GMS 6504 FINAL EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED -partition coefficient log P in -0.4 to +5.6 range -molar refractory from 40 to 130 -molecular weight from 160 to 500 -polar surface no greater than 140A -number of atoms from 20 to 70s improvements lipinski parameters Hydrogen bond donor functional group -NH2 LogP of hydrophobic molecules High Reason for smaller polar surface areas in CNS drugs It helps the drug cross the blood brain barrier Functional gro...