GMS6540

GMS 6540 CANPHARM PS2 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS GRADED A++ Which class of cancer drugs is the least selective towards cancer cells? Chemotherapy Is chemotherapy generally more effective when tumors are small or large? Small A tumor contains 10^9 cells. After a dose of chemotherapy, there are 750,000 cells remaining. When the second chemotherapy dose is given, the tumor has grown to 800,000 cells. How many cells do you expect to remain after the next dose of chemot...

GMS 6540 CANPHARM PS3 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS What is the process called when two EGFR proteins bind to each other? Dimerization In what location does Cetuximab bind EGFR? Extracellularly What type of immune cells induce ADCC in cells treated with Cetuximab? Natural killer cells If a pt is being treated with Osimertinib, what were they likely treated with previously? Erlotinib What is the endogenous ligand for HER2? It has no known ligand

GMS 6540 (MED PHARM IV): PROBLEM SET 8 EXAM QUESTIONS AND VERIFIED ANSWERS GRADED A++ Would Tamiflu be expected to increase or decrease the number of competent viral particles present in infected cells? Increase Decrease Increase Would Acyclovir be expected to increase or decrease the number of competent viral particles present in infected cells? Increase Decrease Decrease Which drug is most likely to be prescribed for chicken pox? Oseltamavir Acyclovir Ganciclovir Retrovir ...

GMS6540: PROBLEM SETS REVIEW EXAM 1 QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE A patient undergoes outpatient surgery and is given a standard course of antibiotics but ends up back in the hospital a couple days later with a severe clostridium difficile infection. This is an example of which toxicity/complication? superinfection Gram positive bacteria lack what structure when compared to gram negative bacteria outer membrane Which class of antibacterials is bact...

GMS 6540 MODULE 3 TARGETED THERAPY EXAM QUESTIONS AND VERIFIED ANSWERS GRADED A++ Cetuximab tyrosine kinase inhibitor, inhibit ATP binding --> prevents kinase activity, is an antibody, administered as a loading dose + weekly maintenance doses, for colon cancer and head/neck squamous cell carcinoma Erlotinib tyrosine kinase inhibitor, inhibit ATP binding --> prevents kinase activity, competitive inhibitor, oral, primarily for NSCLC with mutant EGFR, rash and diarrhea, met by CYP3A4, PPI...

GMS 6540 MODULE 4 IMMUNOSUPPRESSANT DRUGS EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED 2024/2025 Prednisone corticosteroid, inhibits cytokine production, adv effects: insomnia, hypomania, ulcers Tacrolimus signaling inhibitor, inhibit calcineurin, adv effects: nephro, hepato, neurotoxicity Cyclosporine/Cyclophilin signaling inhibitor, inhibit calcineurin, adv effects: nephro, hepato, neurotoxicity Daclizumab Anti-IL-2 receptor antibody, blocks IL-2 activation (and t-cell...

GMS 6540 MODULE 2 ANTICANCER DRUGS EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS 100% GRADED A++ Cytotoxic Agents Drugs used to kill cancer cells that are actively growing or dividing. Targeted Therapy a developing form of anti-cancer drug therapy that uses drugs or other substances to identify and attack specific cancer cells without harming normal cells Immunotherapy use of immune cells, antibodies, or vaccines to treat or prevent disease DNA Damaging Drugs Cyclophosphamide (DNA...

GMS6540 REVIEW EXAM 2 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE Which component of the CRISPR-Cas9 system determines the location of gene edits? gRNA Which of the following is an aminoglycoside? gentamycin With which drug would an aminoglycoside be synergistic? penicillin Hearing loss as a side effect is most common with which drug? gentamycin Which drug is active against gram positive bacteria as well as mycoplasma? tetracycline Which macrolide would b...

GMS 6540 MODULE 5 ANTIBACTERIALS EXAM QUESTIONS AND ANSWERS WITH VERIFIED COMPLETE SOLUTIONS Penicillin G narrow spectrum, B-lactam drug, primarily on Gram +, inactivated by b-lactamase organisms, short half life Penicillin V narrow spectrum, B-lactam drug, primarily on Gram +, inactivated by b-lactamase organisms, short half life Benzathine Pen G narrow spectrum, B-lactam drug, primarily on Gram +, depot salts of penicillin prolong plasma levels, tx of syphilis or recurrent rheumatic fe...

GMS6540: ANTICANCER DRUGS EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED anticancer therapy classes -cytotoxic agents (chemotherapy) -targeted therapy -immunotherapy cytotoxic agents -also known as chemotherapy -generally target all rapidly proliferating cells -non-specific = hits cancer AND normal cells -mainstay of clinical cancer therapy targeted therapy -cancer specific molecular alterations -lower toxicities -spare normal cells -combined with cytotoxic agents, gen...