GMS6540

GMS6540: ANTIBACTERIALS 2 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED selective toxicity A drug that kills harmful microbes without damaging the host bacterial protein synthesis inhibitors -initiation: aminoglycosides, oxazolidinones -elongation: tetracyclines, macrolides, clindamycin, chloramphenicol bacterial protein synthesis mRNA binds 30s Formylmethionyl tRNA and 50s added to form initiation complex Aminoacyl tRNA adds to ribosome Forms peptide bond Transloca...

GMS 6540 QUIZ QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS What effect would a G12V mutation in Ras have on ERK? It would lead to increased activation of ERK Are cancers more likely to develop mutation that activate or inactivate Rb? inactivate Metabolites of nicotine commonly result in DNA point mutations. Which type of DNA instability is this an example of? genetic instability If a human cell underwent endoreduplication followed by failed cytokinesis, how many chromosomes would you exp...

GMS6540: ANTIBACTERIALS 1 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED purpose of chemotherapy -treatment of active infection -prophylaxis = prevent spread of disease selective toxicity/drug targets 1. bacterial = cell wall/membrane, protein synthesis, DNA/RNA synthesis 2. fungal = cell wall/membrane, steroid synthesis 3. viral = DNA/RNA synthesis, absorption/processing/assembly 4. parasitic why so many antibiotics? -spectrum -resistance -pharmacokinetics -adverse eff...

GMS6540: IMMUNOSUPRESSANT DRUGS EXAM QUESTIONS AND VERIFIED ANSWERS GRADED A++ purpose of immunosuppressive drugs -prevention of organ transplant rejection -treatment of autoimmune diseases = multiple sclerosis, lupus, rheumatoid arthritis, crohn's disease, and type I diabetes cellular basis for organ transplant rejection 1. antigen presenting cell (APC) activates T cells 2. T cells produce Interleukin 2 (IL2) 3. IL2 stimulates the proliferation of T cells and the production of additio...

GMS6540: TARGETED THERAPIES EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED growth factors -stimulate the growth and division of cells growth factor receptors important in cancer -epidermal growth factor receptor = EGFR -human epidermal growth factor receptor 2= HER2/Neu -platelet derived growth factor receptor = PDGFR EGFR -sits on transmembrane protein -receptor part is extracellular -EGF ligand binds = dimerization -intracellular parts form dimer = kinase domain -aut...

GMS6540: ANTIFUNGALS AND ANTIPARASITICS EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED antifungal drugs -fungal cell wall made up of beta-glucans -beta-glucan synthase makes precursor of the cell wall -ergosterol in membranes (instead of cholesterol) -different drugs target different parts systemic antifungal drugs -amphotericin B -caspofungin -flucytosine -itraconazole superficial antifungal drugs -nystatin -miconazole -terbinafine Amphotericin B -systemic antifunga...

GMS6540: VIRAL PHARMACOLOGY EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED viral chemotherapy -viral pathogens use host and cell machinery to do the work -bring in some viral specific proteins 1. virus binds to host cell = entry process occurs 2. once it penetrates it has to uncoat before early protein synthesis 3. after early protein synthesis it undergoes nucleic acid synthesis 4. after nucleic acid synthesis = late protein synthesis and processing occurs 5. package and as...

GMS6540 PART 2 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE gram negative bacteria outer membrane - peptidoglycan - inner membrane gram positive bacteria peptidoglycan - inner membrane B-lactam drugs inhibit cell wall synthesis by inhibiting transpeptidase b-lactam ring is sterically unstable and reacts with active site of transpeptidase in a covalent fashion adverse effects of b-lactam drugs allergic reactions (penicillin is a hapten) superinfection: kn...

GMS6540: DRUGS TO KNOW EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED S phase drugs -5-FU -methotrexate *these are phase-specific microtubule phase drugs (M) -paclitaxel -vincristine *these are phase-specific proliferation-dependent toxicities (chemotherapy) -bone marrow = myleosuppression -gut mucosa = mucositis -hair follicles = alopecia -germ cells = teratogenicity and temporary/permanent sterility (cyclophosphamide) -second malignancies hemorrhagic cystitis ...

GMS6540 - ALL DRUGS EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS GRADED A++ MODULE 2 DNA damaging drugs (2) Cyclophosphamide (DNA alkylating agent) Cisplatin Topoisomerase II drugs (2) Doxorubicin, Etoposide Microtubule drugs (2) Vincristine Paclitaxel Antimetabolites (3) Methotrexate5-Fluorouracil (5-FU)Cytosine arabinoside (Ara C) Protein tyrosine kinase inhibitors (1) Imatinib Cyclophosphamide mechanism Alkalating agent; DNA cross links Haemorrhagic cystitis, Mye...